杨丽群

特聘教授、硕士生导师

简历：

主要科研领域与方向:

家蚕和小鼠疾病模型的建立；家蚕及小鼠血液和神经疾病的发生发展的机理研究；从事医学基础研究肿瘤干细胞生物学以及昆虫干细胞等发育及细胞生物学领域。

科学成就：

主要从事家蚕疾病模型的建立及致病机理的研究；家蚕干细胞的研究；血液和神经肿瘤发生发展的机理及肺部炎症、自身免疫性疾病和多发性骨髓瘤等疾病模型建立等医学基础研究；参与“973”项目、美国NIH、美国癌症协会及俄亥俄州、佐治亚州政府资助的多项课题。现主持国家自然科学基金2项，重庆市自然科一项等科研课题。发表研究论文20余篇。获得2015年重庆市自然科学二等奖。

代表性论文/论著（*为通讯作者）

1. Yang L, Ke XX, Xuan F, Tan J, Hou J, Wang M, Cui H, Zhang Y. PHOX2B Is Associated with Neuroblastoma Cell Differentiation. Cancer Biother Radiopharm. 2016 Mar;31(2):44-51.

2. Zhao E, Ding J, Xia Y, Liu M, Ye B, Choi JH, Yan C, Dong Z, Huang S, Zha Y, Yang L, Cui H, Ding HF. KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. Cell Rep. 2016 Jan 26;14(3):506-19.

3. Hu H, Dong Z, Tan P, Zhang Y, Liu L, Yang L, Liu Y, Cui H. Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner. Oncotarget. 2016 Jan 19;7(3):3171-85.

4. Xuan F, Huang M, Liu W, Ding H, Yang L*, Cui H*. Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1. Neuro Oncol. 2016 Jun;18(6):819-29

5. Zhao H*, Yang L*, Cui H. SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells. Biochem Biophys Res Commun. 2015 Sep 4;464(4):1163-70.

6. Zhang K, Su J, Chen S, Yu S, Tan J, Xu M, Liang H, Zhao Y, Chao H, Yang L, Cui H. Molecular cloning, characterization and expression analysis of cathepsin O in silkworm Bombyx mori related to bacterial response. Mol Immunol. 2015 Aug;66(2):409-17.

7. Peng H, Ke XX, Hu R, Yang L, Cui H, Wei Y. Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Mol Med Rep. 2015 Feb;11(2):881-6.

8. Wang X*, Yang L*, Choi JH, Kitamura E, Chang CS, Ding J, Lee EJ, Cui H, Ding HF. Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells. Genom Data. 2014 Dec 1;2:50-52.

9. Tang C*, Yang L*, Jiang X, Xu C, Wang M, Wang Q, Zhou Z, Xiang Z, Cui H. Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells. Biochem Biophys Res Commun. 2014 Mar 28;446(1):105-12.

10. J Ding, T Li,X wang, E zhao, L Yang, Hongjuan Cui and Han-Fei Ding. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation，Cell Metabolism, 2013, in press.

11. Wang X*, Choi JH*, Ding J*, Yang L*, Ngoka LC, Cui H, Ding HF. HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation. BMC Genomics, 2013 Nov 25;14(1):830. [Epub ahead of print]

12. Zha Y, Ding E, Yang L, Mao L, Wang X, McCarthy BA, Huang S, Ding HF. Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation. PLoS One. 2012;7(8):e40728.

13. McCarthy BA*, Yang L*, Ding J, Ren M, King W, ElSalanty M, Zakhary I, Sharawy M, Cui H, Ding HF. NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors. BMC Cancer, 2012, 12:203,203-215.

14. L Mao, J Ding, A Perdue1, L Yang, Y Zha, M Ren, S Huang, H Cui* and H-F Ding. Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression. Oncogene (2012) 31, 3785–3795.

15. Mao L*, Ding *J, Zha Y*, Yang *L, McCarthy BA, King W, Cui H, Ding HF, HOXC9 links cell cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. Cancer Res., 2011. 71(12):4314-4324.

16. Yang L, Cui H, Wang Z, Zhang B, Ding J, Liu L, Ding HF. Loss of negative feedback control of nuclear factor-kappaB2 activity in lymphocytes leads to fatal lung inflammation. Am J Pathol. 2010 Jun;176(6):2646-5

17. Alam G, Cui H, Shi H, Yang L, Ding J, Mao L, Maltese WA, Ding HF. MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. Am J Pathol. 2009 Aug;175(2):856-66.

18. Wang Z, Zhang B, Yang L, Ding J, Ding HF. Constitutive production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression. J Biol Chem. 2008 Apr 18;283(16):10698-706.

19. 杨丽群 ，徐曼，崔红娟，家蚕(Bombyx mori)血细胞研究进展，蚕业科学，2015，（06）：973-978。

20. 杨丽群，贾乐梅，唐梅，陈毅彪，崔红娟 家蚕BmYki-1基因鉴定与表达特征《中国农业科学》,2016(08):1607-1616

21. 王梓任，陆天琳，徐曼，杨丽群 家蚕免疫血清体外抑制神经母细胞瘤细胞生长和增殖《蚕学通讯》,2015,35(4)

联系地址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716

电话：13018364965

传真：

E-mail：cysylq@swu.edu.cn