刘同宝

教授、硕士生导师

简历：

教育经历：

工作经历：

主要科研领域与方向:

病原真菌分子生物学

科学成就：

主要从事病原真菌致病机理工作，研究材料包括新生隐球菌、稻瘟病菌和球孢白僵菌。美国微生物学会会员，国际人类与动物病原真菌学会会员。开展了蛋白质降解途径（包括细胞自噬和泛素化蛋白降解）控制真菌致病性的机理研究，并取得了重要进展。主持国家自然科学基金、中央高校基本业务费重大项目等多项课题，在《Autophagy》、《PLoS Pathogens》、《Infection and Immunity》等国内外学术杂志发表研究论文20余篇，参编专著2本，并获邀参加美国戈登会议（GRC）并做大会特邀报告。

代表性论文/论著：

1. Liu T.B., Subbian S., Pan W., Eugenin E., Xie J. and Xue C. (2014) Cryptococcus inositol utilization modulates the host protective immune response during brain infection. Cell Communication and Signaling. 2014 Sep 10; 12(1):51.

2. Liu T.B., Liu X.H., Lu J.P., Zhang L., Min H., Lin F.C. (2010) The cysteine protease MoAtg4 interacts with MoAtg8 and is required for differentiation and pathogenesis in Magnaporthe oryzae. Autophagy, 6(1): 74-85.

3. Liu T.B., Kim J.C., Wang Y, Toffaletti D.L., Eugenin E, et al. (2013) Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier. PLoS Pathog 9(4): e1003247. doi:10.1371/journal.ppat.1003247.

4. Liu T.B., Xue C. (2014) The Fbp1-mediated ubiquitin-proteasome pathway controls Cryptococcus virulence by regulating fungal intracellular growth in macrophages. Infection and Immunity. 82(2): 557-568. doi:10.1128/IAI.00994-13.

5. Liu T.B., Wang Y., Barker G.M., Fahmy H., Jiang L., Xue C. (2013) The Glucose Sensor-Like Protein Hxs1 Is a High-Affinity Glucose Transporter and Required for Virulence in Cryptococcus neoformans. PLoS ONE 8(5): e64239. doi:10.1371/journal.pone.0064239.

6. Magditch D.A., Liu T.B., Xue C, Idnurm A (2012) DNA Mutations Mediate Microevolution between Host-Adapted Forms of the Pathogenic Fungus Cryptococcus neoformans. PLoS Pathog 8(10): e1002936. doi:10.1371/journal.ppat.1002936.

7. Liu T.B., Perlin D., Xue C. (2012) Molecular mechanism of cryptococcal meningitis. Virulence. 3(2): 1-9.

8. Liu T.B., Xue C. (2011) The Ubiqutin-Proteasome System and F-box Proteins in pathogenic fungi. Mycobiology. 39(4): 243-248.

9. Liu T.B., Wang Y., Stukes S., Chen Q., Casadevall A., Xue C. (2011) The F-Box protein Fbp1 regulates sexual reproduction and virulence in Cryptococcus neoformans. Eukaryot Cell. 10(6): 791-802.

10. Wang Y., Liu T.B. (co-first authors), Delmas G., Park S., Perlin D., Xue C. (2011) Two major inositol transporters and their role in cryptococcal virulence. Eukaryot Cell. 10(5): 618-28.

11. Xue, C., Liu, TB., Chen, L., Li, W., Liu, I., Kronstad J.W., Seyfeng, A., and Heitman, J. (2010) Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. mBio, 1(1): e00084-10.

12. Liu T.B., Chen G.Q., Min H., Lin F.C. (2009) MoFLP1, encoding a novel fungal fasciclin-like protein, is involved in conidiation and pathogenicity in Magnaporthe oryzae. Zhejiang Univ. SCI. B, 10(6): 434-444.

13. Liu T.B., Lu J.P., Liu X.H., Min H., Lin F.C. (2008) A simple and effective method for total RNA isolation of appressoria in Magnaporthe oryzae. Zhejiang Univ. SCI. B, 9(10): 811-817.

联系地址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716

电    话： 023-68251088

传    真：023-68251288 

E-mail：tongbaoliu@swu.edu.cn