范伟 讲师

资源昆虫高效养殖与利用全国重点实验室

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E-mail（邮件）: fanwei2034@163.com

教育背景

2015-2021 西南大学，家蚕基因组生物学国家重点实验室，遗传学专业，博士

2011-2015 西南大学，生物技术学院，生物技术专业，学士

工作经历

2024-至今 资源昆虫高效养殖与利用全国重点实验室，讲师

2022-2024 西南大家资源昆虫高效养殖与利用全国重点实验室，博士后

研究领域

1) 桑树基因组进化：围绕“桑树如何通过基因组演化适应多样化的生境？”等科学问题，开展桑树多组学比较分析、基因家族进化分析等研究方向。

2）低重金属积累作物种质创制：围绕“重金属转运蛋白结构分析-关键氨基酸位点大规模筛选鉴定-作物基因组精准编辑”流程，改进/开发新型技术，培育低重金属积累新品种。

3）植物免疫受体基因挖掘与设计

学术贡献

主要围绕桑树基因组进化、耐重金属和抗菌核病遗传基础等重要科学问题和产业需求开展研究。主要贡献包括：①明确了“桑-蚕系统”在重金属污染土壤中安全利用和修复的适用性，确定了该系统安全利用土壤的铅、镉浓度范围，首次提出了指导该系统在重金属污染地区应用的决策模型（Science of The Total Environment，2024）；综合分析了已有植物根部的镉转录组数据，发现植物响应镉胁迫的转录模式和决定高/低Cd积累性状基因具有物种特异性（Ecotoxicology and Environmental Safety，2021）；筛选出桑树根部高/低镉积累品种，比较了这些品种在镉胁迫下的多组学水平差异，并率先进行了桑树镉转运和解毒关键的基因鉴定与功能验证（Environmental and Experimental Botany，2022；Frontiers in Plant Science，2018；Gene，2018）；②发现长果桑对桑树肥大性菌核病具有高度抗性，首次揭示了桑实杯盘菌通过柱头侵染桑雌花的机制，且抗病品种的柱头和子房中多个NLR基因显著高表达（Plant Physiology and Biochemistry，2023）。③率先揭示了桑树染色体进化和性别决定遗传基础（Genomics, Proteomics & Bioinformatics，2022）；构建了涵盖112个全球果桑品种的桑椹果色变异大规模数据集，包括表型、全基因组、转录组和代谢组数据（Horticulture Research，2024）。这些研究成果对“立桑为业，多元发展”战略中桑树耐重金属生态优势的发挥及桑树抗菌核病、性别、果色等重要农艺性状改良具有重要意义。

荣誉奖励

暂无

代表性论文

1) Wei Fan, Qiuyue Kong, Yuane Chen, Fuping Lu, Shuchang Wang, Aichun Zhao*. Safe utilization and remediation potential of the mulberry-silkworm system in heavy metal-contaminated lands: A review. Science of The Total Environment, 2024, 927: 172352.

2) Zhongqiang Xia^#, Wei Fan^#, Duanyang Liu, Yuane Chen, Jing Lv, Mengxia Xu, Meirong Zhang, Zuzhao Ren, Xuefei Chen, Xiujuan Wang, Liang Li, Panpan Zhu, Changying Liu, Zhiguang Song, Chuanshu Huang, Xiling Wang, Shuchang Wang, Aichun Zhao*. Haplotype-resolved chromosomal-level genome assembly reveals regulatory variations in mulberry fruit anthocyanin content, Horticulture Research, 2024, uhae120.

3) Wei Fan^#, Shuman Liu^#, Yang Feng, Yazhen Xu, Changying Liu, Panpan Zhu, Shuai Zhang, Zhongqiang Xia, Aichun Zhao*. Stigma type and transcriptome analyses of mulberry revealed the key factors associated with Ciboria shiraiana resistance. Plant Physiology and Biochemistry, 2023, 200: 107743.

4) Zhongqiang Xia^#, Xuelei Dai^#, Wei Fan^#, Changying Liu, Meirong Zhang, Peipei Bian, Yuping Zhou, Liang Li, Baozhong Zhu, Shuman Liu, Zhengang Li, Xiling Wang, Maode Yu, Zhonghuai Xiang, Yu Jiang, Aichun Zhao*. Chromosome-level genomes reveal the genetic basis of descending dysploidy and sex determination in Morus plants, Genomics, Proteomics & Bioinformatics, 2022, 20(6): 1119-1137.

5) Wei Fan, Zhongqiang Xia, Changying Liu, Shuyu Ma, Shuman Liu, Yonghong Wu, Baozhong Zhu, Changzheng Xu, Aichun Zhao*. Ionomics, transcriptomics and untargeted metabolomics analyses provide new insights into the Cd response and accumulation mechanisms of mulberry. Environmental and Experimental Botany, 2022, 196: 104821.

6) Wei Fan, ChangYing Liu, Boning Cao, Shuyu Ma, Jie Hu, Zhonghuai Xiang, Aichun Zhao*. A meta-analysis of transcriptomic profiles reveals molecular pathways response to cadmium stress of Gramineae. Ecotoxicology and Environmental Safety, 2021, 209: 111816.

7) Wei Fan, Changyng Liu, Boning Cao, Meiling Qin, Dingpei Long, Zhonghuai Xiang, Aichun Zhao*. Genome-wide identification and characterization of four gene families putatively involved in cadmium uptake, translocation and sequestration in mulberry. Frontiers in Plant Science, 2018, 9: 879.

8) Wei Fan^#, Qing Guo^#, ChangYing Liu, Xueqin Liu, Meng Zhang, Dingpei Long, Zhonghuai Xiang, Aichun Zhao*. Two mulberry phytochelatin synthase genes confer zinc/cadmium tolerance and accumulation in transgenic Arabidopsis and tobacco. Gene, 2018, 645: 95–104.