杨丽群 教授,博士生导师
资源昆虫高效养殖与利用全国重点实验室
Contact Us(联系方式):
E-mail(邮件): cysylq@swu.edu.cn
简历
2012-至今 资源昆虫高效养殖与利用全国重点实验室 长聘教授
2009-2012 美国佐治亚医科大学 癌症中心 博士后
2005-2006 美国托莱多医科大学 分子与细胞生物学 博士
2000-2003 中国医科大学 免疫学 硕士
1995-2000 中国医科大学 临床医学 学士
研究领域
主要从事疾病模型的建立及致病机理的研究;消化道系统疾病的致病机理;蚕桑活性物质功能研究,调控机制及创新应用。(1)干细胞生物学与医学转化; (2)功能活性物质与肿瘤生物学;(3)蚕桑生物材料与再生医学。
学术贡献
参与国家重点研发计划重点专项项目等多项课题;主持国家自然科学基金2项,重庆市自然科学基金一项;发表研究论文50余篇;获得2016年重庆市自然科学二等奖。
代表性论文
1.Guo Y, Xu M, Hu X, Cen L, Pei D, Zhang D, Xu J, Shi P, Yang L*, Cui H*. Extraction, purification, and mechanism ofimmunomodulatory peptides obtained from silkworm pupa protein hydrolysate. Int J Biol Macromol. 2024 Dec;283(3):137863. 。
2.Xu J, Shi P, Xia F, Zhao X, Chen J, Geng R, Cui H, Yang L*. RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway. Int J Mol Sci. 2022 Oct 10;23(19):12036.
3.Gu H, Zhu S, Peng C, Wei Z, Shen Y, Yuan C, Yang H, Cui H, Yang L*. TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway. Int J Mol Sci. 2022 Sep 5;23(17):10161.
4. Xu J, Li L, Shi P, Cui H, Yang L*. The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies. Int J Mol Sci. 2022 Jul 26;23(15):8231.
5. Ji H, Zhang K, Pan G, Li C, Li C, Hu X, Yang L*, Cui H. Deoxyelephantopin Induces Apoptosis and Enhances Chemosensitivity of Colon Cancer via miR-205/Bcl2 Axis. Int J Mol Sci. 2022 May 2;23(9):5051. Li L, Dong Z, Shi P,
6.Li L, Dong Z, Shi P, Tan L, Xu J, Huang P, Wang Z, Cui H, Yang L*. Bruceine D inhibits Cell Proliferation Through Downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 Axis in Gastric Cancer. Front Pharmacol. 2020 Nov 24;11:584960.
7.Ke XX, Chao H, Abbas MN, Kausar S, Gul I, Ji H, Yang L*, Cui H. Niemann-Pick type C1 regulates cholesterol transport and metamorphosis in silkworm, Bombyx mori (Dazao). Int J Biol Macromol. 2020 Jun 1;152:525-534.
8. Zhu SQ, Zhang YJ, Abbas MN, Hao XW, Zhao YZ, Liang HH, Cui HJ*, Yang L*. Hedgehog promotes cell proliferation in the midgut of silkworm, Bombyx mori. Insect Sci. 2020 Aug;27(4):697-707.
9.Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, Zhang G, Wang X, Dong Z, Chen F, Cui H. Targeting Cancer Stem Cell Pathways for Cancer Therapy; Signal Transduct Target Ther. 2020 Feb 7;5:8.
10. Ma H, Abbas MN, Zhang K, Hu X, Xu M, Liang H, Kausar S, Yang L*, Cui H. 20-Hydroxyecdysone regulates the transcription of the lysozyme via Broad-Complex Z2 gene in silkworm, Bombyx mori. Dev Comp Immunol. 2019 May;94:66-72.
11.Yang L, Zha Y, Ding J, Ye B, Liu M, Yan C, Dong Z, Cui H, Ding HF. Histone Demethylase KDM6B Has an Anti-Tumorigenic Function in Neuroblastoma by Promoting Differentiation;Oncogenesis. 2019 Jan 4;8(1):3.
12.Xuan F, Huang M, Liu W, Ding H, Yang L*, Cui H*. Homeobox C9 Suppresses Beclin1-mediated Autophagy in Glioblastoma by Directly Inhibiting the Transcription of Death-Associated Protein Kinase 1;Neuro Oncol,2016 Jun;18(6):819-29.