博士，教授,博士生导师

教育经历

200508-200910  美国托莱多医科大学 分子与细胞生物学   博士

200009-200307  中国医科大学       免疫学             硕士

199509-200007  中国医科大学       临床医学           本科

工作经历

201202-现在 西南大学,蚕学与系统生物学研究所  教授

主要科研领域与方向

细胞信号转导，干细胞与再生医学，蚕桑活性物质功能研究及创新应用

科学成就

主要从事小鼠及家蚕疾病模型的建立及致病机理的研究；消化道系统疾病的致病机理；蚕桑活性物质功能研究，调控机制及创新应用。参与“973”项目、国家重点研发计划重点专项项目等多项课题；主持国家自然科学基金2项，重庆市自然科学基金一项；表研究论文30余篇；获得2016年重庆市自然科学二等奖。

代表性论文

Xu J, Shi P, Xia F, Zhao X, Chen J, Geng R, Cui H, Yang L. RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway. Int J Mol Sci 2022 Oct 10;23(19):12036.

Gu H, Zhu S, Peng C, Wei Z, Shen Y, Yuan C, Yang H, Cui H,Yang L. TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway. Int J Mol Sci 2022 Sep 5;23(17):10161.

Xu J, Li L, Shi P, Cui H,Yang L. The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies. Int J Mol Sci. 2022 Jul 26;23(15):8231.

Ji H, Zhang K, Pan G, Li C, Li C, Hu X,Yang L, Cui H. Deoxyelephantopin Induces Apoptosis and Enhances Chemosensitivity of Colon Cancer via miR-205/Bcl2 Axis. Int J Mol Sci. 2022 May 2;23(9):5051. 

Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, Zhang G, Wang X, Dong Z, Chen F, Cui H.. Targeting Cancer Stem Cell Pathways for Cancer Therapy; Signal Transduct Target Ther.2020 Feb 7;5:8.

Ke XX, Chao H, Abbas MN, Kausar S, Gul I, Ji H,Yang L, Cui H.；Niemann-Pick type C1 regulates cholesterol transport and metamorphosis in silkworm, Bombyx mori (Dazao). Int J Biol Macromol. 2020 Feb 26;152:525-534.

Li L, Dong Z, Shi P, Tan L, Xu J, Huang P, Wang Z, Cui H,Yang L. Bruceine D inhibits Cell Proliferation Through Downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 Axis in Gastric Cancer. Front Pharmacol.2020 Nov 24;11:584960.

Zhu SQ, Zhang YJ, Abbas MN, Hao XW, Zhao YZ, Liang HH, Cui HJ, Yang LQ.；Hedgehog promotes cell proliferation in the midgut of Silkworm, Bombyx mori, Insect Science, 2019 Mar 27. doi: 10.1111/1744-7917.

Ma H, Abbas MN, Zhang K, Hu X, Xu M, Liang H, Kausar S,Yang L, Cui H, 20-Hydroxyecdysone regulates the transcription of the lysozyme via Broad-Complex Z2 gene in silkworm, Bombyx mori., Developmental & Comparative Immunology, 2019.3.01, 94(05): 66~72

Yang L, Zha Y, Ding J, Ye B, Liu M, Yan C, Dong Z, Cui H, Ding HF. Histone Demethylase KDM6B Has an Anti-Tumorigenic Function in Neuroblastoma by Promoting Differentiation；Oncogenesis. 2019 Jan 4;8(1):3.