童晓玲

博士，副研究员，硕士生导师

耶鲁大学博士后

美国鳞翅目学者协会会员

简历：

主要科研领域与方向:

1．遗传与发育生物学。主要以家蚕为对象，研究重要性状的遗传与分子调控。以家蚕突变遗传资源为材料，重点研究胚胎致死、翅发育缺陷和雌、雄性特异性不育等性状的遗传基础与分子病理机制，寻找鳞翅目害虫生物防控的理想靶标。

2．鳞翅目昆虫分子进化。利用生物信息学分析、转录组、功能基因组、基因编辑等多种手段，以家蚕、野蚕为研究对象，并与蝴蝶等其他鳞翅目昆虫做比较，研究基因-发育-进化等生命本质，尤其关注家蚕重要驯化性状的分子基础解析。

科学成就：

主要从事鳞翅目昆虫遗传、发育和基因功能比较研究。已完成了多个家蚕胚胎致死、翅发育缺陷和生殖缺陷突变的定位克隆和分子机制研究；通过蝴蝶和家蚕基因功能比较研究，阐释了Hox基因、蜕皮激素在适应性进化中的作用。主持国家自然科学基金面上项目1项（31472153）、青年基金1项（30901053）、重庆市科技人才培养计划（创新青年科技人才培养项目）1项（cstc2014kjrc-qnrc0009）和中央高校基本科研业务费重大培育项目1项（XDJK2013A001）；主研863课题、多项国家自然科学基金及省部级项目、美国国家自然科学基金(NSF)项目 (IOS 1146933，PHY 0957680 )等高层次课题；在包括PLoS genetics, Developmental biology, Journal of Biological Chemistry, Genetics, Heredity, Scientific Reports, Insect Molecular Biology等著名SCI杂志在内的国内外学术期刊发表论文20余篇，其中第一作者（或同等贡献第一作者）8篇；参编出版译著《鳞翅目昆虫的分子生物学和遗传学》。参加第60届美国鳞翅目昆虫学会年会（2011，美国）、第二届（2012，中国）和第四届（2015，韩国）亚太地区蚕业及昆虫生物技术大会国际会议、第二届国际昆虫基因组学大会（2015，中国）等国际学术会议， 并做大会报告或分会报告。为自然科学基金评审专家和 Scientific Reports、Insect science、PloS one和Molecular Biology Reports等SCI杂志审稿人。获重庆市2016年高校青年教师教学竞赛三等奖、西南大学第十一届教师教学比赛一等奖（2016）、西南大学青年教师成才奖（2016）等奖励和称号。

代表性论文：

1. Tong, X., He, S., Chen, J., Hu, H., Xiang, Z., Lu, C., and Dai, F. (2015). A novel laminin beta gene BmLanB1-w regulates wing-specific cell adhesion in silkworm, Bombyx mori. Scientific reports 5, 12562.

2. Chen, P. ＃, Tong, X.L. ＃ (Co-first author), Fu, M.Y., Hu, H., Song, J.B., He, S.Z., Gai, T.T., Dai, F.Y., and Lu, C. (2016). Molecular mapping and characterization of the silkworm apodal mutant. Scientific reports. 6: 18956. DOI: 10.1038/srep18956.

3. Tan, D. ＃, Tong, X.L. ＃ (Co-first author), Hu, H., Wu, S.Y., Li, C.L., Xiong, G., Xiang, Z.H., Dai, F.Y., and Lu, C. (2016). Morphological characterization and molecular mapping of an irradiation-induced Speckled mutant in the silkworm, Bombyx mori. Insect molecular biology. 25(2): 93 -104.

4. Tong, X., Hrycaj, S., Podlaha, O., Popadic, A., and Monteiro, A. (2014). Over-expression of Ultrabithorax alters embryonic body plan and wing patterns in the butterfly Bicyclus anynana. Developmental biology 394, 357-366.

5. Tong, X., Lindemann, A., and Monteiro, A. (2012). Differential involvement of Hedgehog signaling in butterfly wing and eyespot development. PloS one 7, e51087.

6. Monteiro, A., Tong, X., Bear, A., Liew, S.F., Bhardwaj, S., Wasik, B.R., Dinwiddie, A., Bastianelli, C., Cheong, W.F., Wenk, M.R., et al. (2015). Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs. PLoS genetics 11, e1005529.

7. Songyuan Wu, Xiaoling Tong, Chenxing Peng, Gao Xiong, Kunpeng Lu, Hai hu, Duan Tan, Chunlin Li, Minjin Han, Cheng Lu & Fangyin Dai*. (2016). Comparative analysis of the integument transcriptomes of the black dilute mutant and the wildtype silkworm Bombyx mori. Scientific Reports, 6:26114. DOI: 10.1038/srep26114.

8. Ya-Ru Lu, Song-Zhen He, Xiao-Ling Tong, Min-Jin Han, Chun-Lin Li, Zhi-Quan Li, and Fang-Yin Dai*. (2016). Microarray analysis of New Green Cocoon associated genes in silkworm, Bombyx mori. Insect Science, 23: 386-395.

9. Songzhen He, Xiaoling Tong, Kunpeng Lu, Yaru Lu, Jiangwen Luo, Wenhao Yang, Min Chen, Min-jin Han, Hai Hu, Cheng Lu, Fangyin Dai*, (2016). Comparative analysis of transcriptomes among Bombyx mori strains and sexes reveals the genes regulating melanic morph and the related phenotypes. PLoS one, 11(5): e0155061.

10. Chen, C., Song, J., Chen, M., Li, Z., Tong, X., Hu, H., Xiang, Z., Lu, C., and Dai, F. (2016). Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori. Biogerontology. 17: 373-381.

11. Song, J., Li, Z., Tong, X., Chen, C., Chen, M., Meng, G., Chen, P., Li, C., Xin, Y., Gai, T., et al. (2015). Genome-wide identification and characterization of Fox genes in the silkworm, Bombyx mori. Functional & integrative genomics 15, 511-522.

12. Meng, G., Dai, F., Tong, X., Li, N., Ding, X., Song, J., and Lu, C. (2015). Genome-wide analysis of the WW domain-containing protein genes in silkworm and their expansion in eukaryotes. Molecular genetics and genomics : MGG 290, 807-824.

13. Li, C., Zuo, W., Tong, X., Hu, H., Qiao, L., Song, J., Xiong, G., Gao, R., Dai, F., and Lu, C. (2015). A composite method for mapping quantitative trait loci without interference of female achiasmatic and gender effects in silkworm, Bombyx mori. Animal genetics 46, 426-432.

14. Dai, F., Qiao, L., Cao, C., Liu, X., Tong, X., He, S., Hu, H., Zhang, L., Wu, S., Tan, D., et al. (2015). Aspartate Decarboxylase is Required for a Normal Pupa Pigmentation Pattern in the Silkworm, Bombyx mori. Scientific reports 5, 10885.

15. Qiao, L., Xiong, G., Wang, R.X., He, S.Z., Chen, J., Tong, X.L., Hu, H., Li, C.L., Gai, T.T., Xin, Y.Q., et al. (2014). Mutation of a cuticular protein, BmorCPR2, alters larval body shape and adaptability in silkworm, Bombyx mori. Genetics 196, 1103-1115.

16. Monteiro, A., Chen, B., Ramos, D.M., Oliver, J.C., Tong, X., Guo, M., Wang, W.K., Fazzino, L., and Kamal, F. (2013). Distal-less regulates eyespot patterns and melanization in Bicyclus butterflies. Journal of experimental zoology. Part B, Molecular and developmental evolution 320, 321-331.

17. Chen, P. ＃, Tong, X.L. ＃ (Co-first author), Li, D.D., Fu, M.Y., He, S.Z., Hu, H., Xiang, Z.H., Lu, C., and Dai, F.Y. (2013). Antennapedia is involved in the development of thoracic legs and segmentation in the silkworm, Bombyx mori. Heredity 111, 182-188.

18. Chen, P., Tong, X.L., Li, D.D., Liang, P.F., Fu, M.Y., Li, C.F., Hu, H., Xiang, Z.H., Lu, C., and Dai, F.Y. (2013). Fine mapping of a supernumerary proleg mutant (E(Cs) -l) and comparative expression analysis of the abdominal-A gene in silkworm, Bombyx mori. Insect molecular biology 22, 497-504.

19. Qiao, L., Li, Y., Xiong, G., Liu, X., He, S., Tong, X., Wu, S., Hu, H., Wang, R., Hu, H., et al. (2012). Effects of altered catecholamine metabolism on pigmentation and physical properties of sclerotized regions in the silkworm melanism mutant. PloS one 7, e42968.

20. Oliver, J.C., Tong, X.L., Gall, L.F., Piel, W.H., and Monteiro, A. (2012). A single origin for nymphalid butterfly eyespots followed by widespread loss of associated gene expression. PLoS genetics 8, e1002893.

21. Everett, A., Tong, X., Briscoe, A.D., and Monteiro, A. (2012). Phenotypic plasticity in opsin expression in a butterfly compound eye complements sex role reversal. BMC evolutionary biology 12, 232.

22. Dai, F.Y. ＃, Qiao, L. ＃, Tong, X.L. ＃ (Co-first author), Cao, C., Chen, P., Chen, J., Lu, C., and Xiang, Z.H. (2010). Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant. The Journal of biological chemistry 285, 19553-19560.

23. Tong, X.L., Dai, F.Y., Su, M.K., Ma, Y., Tan, D., Zhang, Z., He, N.J., Xia, Q.Y., Lu, C., and Xiang, Z.H. (2008). Identification and expression of the achaete-scute complex in the silkworm, Bombyx mori. Insect molecular biology 17, 395-404.

联系地址：重庆市北碚区天生路2号，西南大学家蚕基因组生物学国家重点实验室（南校区科技楼406），400716

电　　话：023-68250551

传　　真：023-68251128

E-mail：xltong@swu.edu.cn

        xiaoling.tonger@gmail.com