董振 副教授，硕士生导师

资源昆虫高效养殖与利用全国重点实验室

Contact Us（联系方式）：15086916685；023-68253750
E-mail（邮件）: zdong007@swu.edu.cn

教育背景

2012.09-2017.06，西南大学，遗传学专业，理学博士

2008.09-2012.06，安徽农业大学，应用生物科学专业，理学学士

工作经历

2021.07-至今，西南大学，资源昆虫高效养殖与利用全国重点实验室，副研究员

2019.12-2021.07，西南大学，家蚕基因组生物学国家重点实验室，讲师

2017.07-2019.10，西南大学，畜牧学博士后流动站，博士后

研究领域

（1）资源昆虫及其饲源植物功能活性物质的医学研究与转化：筛选资源昆虫及其饲源植物来源的中药材如白僵蚕、桑白皮、桑枝、桑葚、霜桑叶、桑黄、桑寄生等，及新型功能性食品如蚕蛹油中的功能活性物质如黄酮、酚酸、生物碱、脂类等，探索其抑癌、抗氧化、调节代谢等生物医学活性，开发新型保健食品和药品，推动其在人类健康和疾病如肿瘤、代谢性及退行性疾病中的应用。

（2）细胞代谢与表观遗传相互调控的分子机制：阐释活性物质及核心靶点在人类健康和疾病中的作用，重点围绕其对表观遗传调控如DNA修饰、组蛋白修饰、染色质重塑、非编码RNA和相分离，以及细胞代谢如糖代谢、脂代谢、氨基酸代谢、核苷酸代谢等作用，并解析表观遗传和细胞代谢相互调控的分子机制。

学术贡献

系统分析了桑树来源中药材活性物质的种类及其相对成分；首次在其中筛选出具备抗癌、降胆固醇的成分——桑根皮醇（Morusinol），并解析了其作用和机制；鉴定Morusin抑制有氧糖酵解的作用及其靶点；同时探索了多个表观遗传调控相关靶点如Sirtuins家族多个成员在肿瘤代谢与增殖中的作用。已发表学术论文40余篇（H-index：24，引用超2700次），其中以第一作者、共同第一作者或通讯作者在Seminars in Cancer Biology、British Journal of Cancer、Phytomedicine、Journal of Agricultural and Food Chemistry、Journal of Pharmaceutical Analysis、Frontiers in Immunology、Cells及Frontiers in Cell and Developmental Biology等杂志累计发表SCI论文20余篇。主持国家自然科学基金青年项目1项、重庆市自然科学基金面上项目1项、重庆市博士后研究人员特别资助项目1项、教育部中央高校基本科研业务费专项1项、西南大学博士启动基金1项。现为重庆市实验动物协会理事、西南大学实验动物委员会委员、重庆市抗癌协会肿瘤标志物专业委员会委员、重庆市医学会计划生育学与优生优育分会委员会男性生殖调控学组成员。任Frontiers杂志Gastrointestinal Cancers: Colorectal Cancer领域副主编和Cancer Immunity and Immunotherapy领域评审编辑，为Phytomedicine、Journal of Biomedical Science、Cell Communication and Signaling、Biomarker Research、Frontiers in Immunology以及Frontiers in Cell and Developmental Biology等多家学术期刊审稿人。

荣誉奖励

2018重庆市科学技术委员会自然科学优秀学术论文。

代表性论文

1）Dong, Z.; Cui, H.*, Epigenetic modulation of metabolism in glioblastoma. Seminars in cancer biology 2019, 57, 45-51.

2）Zhang, X.#; Dong, Z.#; Yang, Y.; Liu, C.; Li, J.; Sun, W.; Zhu, Y.; Shen, Y.; Wang, Z.; Lü, M.*; Cui, H.*, Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. Journal of agricultural and food chemistry 2023, 71 (43), 16016-16031.

3）Guo, L.#; Dong, Z.#; Zhang, X.; Yang, Y.; Hu, X.; Ji, Y.; Li, C.; Wan, S.; Xu, J.; Liu, C.; Zhang, Y.; Liu, L.; Shi, Y.; Wu, Z.; Liu, Y.*; Cui, H.*, Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway. Phytomedicine 2023, 114, 154765.

4）Dong, Z.; Lei, Q.; Yang, R.; Zhu, S.; Ke, X. X.; Yang, L.; Cui, H.*; Yi, L.*, Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma. British journal of cancer 2017, 116 (12), 1572-1584.

5）Dong, Z.#; Hu, R.#; Du, Y.; Tan, L.; Li, L.; Du, J.; Bai, L.; Ma, Y.; Cui, H.*, Immunodiagnosis and Immunotherapeutics Based on Human Papillomavirus for HPV-Induced Cancers. Frontiers in immunology 2020, 11, 586796.

6）Zhu, S.#; Dong, Z.#; Ke, X.; Hou, J.; Zhao, E.; Zhang, K.; Wang, F.; Yang, L.; Xiang, Z.; Cui, H.*, The roles of sirtuins family in cell metabolism during tumor development. Seminars in cancer biology 2019, 57, 59-71.

7）Dong, Z.#; Yang, J.; Li, L.; Tan, L.; Shi, P.; Zhang, J.; Zhong, X.; Ge, L.; Wu, Z.*; Cui, H.*, FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma. International journal of oncology 2020, 56 (3), 728-742.

8）Dong, Z.; Zhong, X.; Lei, Q.; Chen, F.*; Cui, H.*, Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells. Cellular signalling 2019, 60, 100-113.

9）Dong, Z.*; Cui, H.*, The Emerging Roles of RNA Modifications in Glioblastoma. Cancers 2020, 12 (3).

10）Dong, Z.; Pu, L.; Cui, H.*, Mitoepigenetics and Its Emerging Roles in Cancer. Frontiers in cell and developmental biology 2020, 8, 4.

11）Dong, Z.; Cui, H.*, The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors. Cells 2018, 8 (1).

12）Zhang, X.#; Dong, Z.#*; Cui, H.*, Interplay between Epigenetics and Cellular Metabolism in Colorectal Cancer. Biomolecules 2021, 11 (10).

13）Dong, Z.; Abbas, M. N.; Kausar, S.; Yang, J.; Li, L.; Tan, L.; Cui, H.*, Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers. International journal of molecular sciences 2019, 20 (14).

14）董振,雷倩,刘力超,崔红娟*.长寿蛋白SIRT6在肿瘤发生发展中的作用[J].生物工程学报,2016,32(07):870-879.

15）Ji, Y.#; Li, C.#; Wan, S.#; Dong, Z.#; Liu, C.; Guo, L.; Shi, S.; Ci, M.; Xu, M.; Li, Q.; Hu, H.; Cui, H.*; Liu, Y.*, Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy. Journal of pharmaceutical analysis 2024, 14 (10), 101036.

16）Du, J.#; Dong, Z.#; Tan, L.; Tan, M.; Zhang, F.; Zhang, K.; Pan, G.; Li, C.; Shi, S.; Zhang, Y.; Liu, Y.; Cui, H.*, Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma. Frontiers in cell and developmental biology 2020, 8, 607757.

17）Li, L.#; Dong, Z.#; Shi, P.; Tan, L.; Xu, J.; Huang, P.; Wang, Z.; Cui, H.*; Yang, L.*, Bruceine D inhibits Cell Proliferation Through Downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 Axis in Gastric Cancer. Frontiers in pharmacology 2020, 11, 584960.

18）Hu, R.#; Dong, Z.#; Zhang, K.; Pan, G.; Li, C.; Cui, H.*, Preparation, Characterization and Diagnostic Valuation of Two Novel Anti-HPV16 E7 Oncoprotein Monoclonal Antibodies. Viruses 2020, 12 (3).

19）Z. Dong & H. Cui, Chapter 11 - Sirtuins and cellular metabolism in cancers, in Book: K. Maiese (Ed.), Sirtuin Biology in Cancer and Metabolic Disease, Academic Press. 2021, pp. 195-217. (Chapter)