助理研究员

简历：

2003-2007   西南大学   生物科学          学士

2007-2010   四川大学   移植科学与工程学     硕士研究生

2010-2014   西南大学   特种经济动物饲养     博士研究生

2015-2017   西南大学   生物学          博士后

2017-      西南大学   细胞生物学        助理研究员

主要科研领域与方向：

细胞增殖的表观遗传调控机制

‍科学成就：

主要研究方向为肿瘤细胞表观遗传调控、肿瘤细胞增殖及肿瘤干细胞研究。主持国家自然科学基金青年项目1项，重庆市基础科学与前沿技术研究项目1项，重庆市博士后基金1项，中央高校基本科研业务费项目1项，西南大学博士基金项目1项；主研“973”计划课题1项、科技部重点研发计划2项、国家自然科学基金2项，省部级项目3项；获2018年国家公派访问学者项目资助，在美国University of Alabama at Birmingham访问交流一年。以第一作者在 Oncology Reports、Oncol Letter、ISJ - Invertebrate Survival Journal等杂志上发表SCI论文3篇。

代表性论文/论著：

1. Xiao-Xue Ke, Yi Pang, Kuijun Chen, Dunke Zhang, Feng Wang, Jingxin Mao, Xiaosong Hu, Guanghui Zhang, Hongjuan Cui. Knockdown of arsenic resistance protein 2 (Ars2) inhibited human glioblastoma cell proliferation through the MAPK/ERK pathway. Oncology Reports. 2018. Accepted.

2. Xiao-Xue Ke, Dunke Zhang, Hailong Zhao, Renjian Hu, Zhen Dong, Rui yang, Shunqin Zhu, Qingyou Xia, Han-Fei Ding, Hongjuan Cui. Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development. Oncology Letter. 2015, 9: 2507-2514.

3. Xiao-Xue Ke, Hongyan Gao, Kuijun Chen, Lei Zhang, Siyuan Chen, Xue Wang, Zhuanqin Wei, Liqun Yang, Hongjuan Cui. Identification of BmBrat gene in silkworm, Bombyx mori.. ISJ - Invertebrate Survival Journal. 2018, 15: 149-157.

4. Liqun Yang#, Xiao-Xue Ke # (Co-first author), Fan Xuan, Juan Tan, Jianbing Hou, Mei Wang, Hongjuan Cui, Yundong Zhang. PHOX2B is associated with neuroblastoma cell differentiation. Cancer Biotherapy and Radiopharmaceuticals. 2016, 31(2): 44-51.

5. Xiaomin Yan#, Xiao-Xue Ke # (Co-first author), Hailong Zhao, Mengying Huang, Renjian Hu, Hongjuan Cui. Triptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells. Molecular Medicine Reports. 2015, 11 (2): 791-796.

6. Dunke Zhang, Feng Wang, Yi Pang, Xiao-Xue Ke, Shunqin Zhu, Erhu Zhao, Kui Zhang, Lixue Chen, Hongjuan Cui. Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction. Oncotarget. 2017, 8(46): 80956–80970.

7. Feng Wang, Dunke Zhang, Jingxin Mao, Xiao-Xue Ke, Rui Zhang,Chao Yin, Ning Gao, Hongjuan Cui. Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer. Oncotarget. 2017, 8(34): 57187–57200.

8. Zhen Dong, Qian Lei, Rui Yang, Shunqin Zhu, Xiao-Xue Ke, Liqun Yang, Hongjuan Cui, Liang Yi. Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma. British Journal of Cancer. 2017, 116: 1572–1584.

9. Hongwei Peng, Xiao-Xue Ke, Renjian Hu, Liqun Yang, Hongjuan Cui, Yuquan Wei. Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells. Molecular Medicine Reports. 2015, 11(2): 881-886. 

10. Jifu Li, Shunqin Zhu, Xiao-Xue Ke, Hongjuan Cui. Role of several histone lysine methyltransferases in tumor development. Biomedical Reports. 2016, 4(3):293-299.

联系地址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716

电        话： 023-68250079

E-mail：kexiaoxue@126.com