研究员、博士生导师

国际学术身份认证编码(ORCID)：https://orcid.org/0000-0002-2917-0172.

简历：

主要科研领域与方向:

研究领域：非编码RNA和基因调控

研究方向：1. 非编码RNA对蚊子吸血、繁殖和病原传播的调控机制；2. 非编码RNA和激素在家蚕和蚊子等昆虫中的协同作用机制。3. 家蚕丝腺中的非编码RNA调控。

招生专业：生物化学与分子生物学、遗传学

科学成就：

长期从事非编码RNA和基因调控研究，在家蚕和蚊子等昆虫非编码RNA研究领域获得了一系列重要研究成果：（1）系统性地开展并完成了家蚕个体、组织和细胞中microRNA的鉴定和时空表达模式研究；（2）在家蚕丝腺中建立起小RNA功能研究的遗传操作体系，发现let-7 miRNA通过靶向调节营养代谢和能量代谢通路基因而控制丝腺的生长和丝蛋白合成；（3）系统性地鉴定了不同昆虫细胞系、组织和个体中蜕皮激素应答性miRNA，揭示了蜕皮激素信号通路和miRNA信号通路之间的桥联机制；（4）揭示了蚊子吸血和血液消化的分子机制，发现吸血蚊子特有和中肠特异miR-1174和靶基因SHMT为蚊子吸血和血液消化所必须，进而控制蚊子卵的成熟和蚊子繁殖。

以第一作者或通讯作者在PNAS、RNA Biology、BMC Genomics和Parasites Vector等学术期刊发表了10多篇研究论文，以共同作者在Science、PNAS和Development等学术期刊发表了20多篇研究论文。主持国家自然基金面上项目、家蚕973项目子课题和重庆市自然基金等共7项。担任非编码RNA研究重大专项、国家自然基金面上和青年项目通讯评审，教育部学位论文评审专家，一些省市“杰青”和“优青”人才项目评审专家。多次应邀在美国昆虫学会、国际RNA学会和国际遗传学会等重要学术会议上做学术报告。已为Molecular Autism、BMC Genomics、IBMB和Insect science等20多种国际学术期刊审稿。国际RNA学会、美国昆虫学会、中国生物化学与分子生物学学会会员。

代表性论文/论著：

[1] Xiaoli Jin, Xiaoyan Wu, Lanting Zhou, Ting He, Quan Yin & Shiping Liu*. 20-Hydroxyecdysone-responsive microRNAs of insects, RNA Biology, 2020, 17:10, 1454-1471. https://doi.org/10.1080/15476286.2020.1775395. (IF₂₀₂₀=5.35)

[2] Wei Wang, Xinran Wang, Chengyi Luo, Qian Pu, Quan Yin, Lili Xu, Xinyue Peng, Sanyuan Ma, Qingyou Xia & Shiping Liu*. Let-7 microRNA is a critical regulator in controlling the growth and function of silk gland in the silkworm, RNA Biology, 2020, 17:5, 703-717. https://doi.org/10.1080/15476286.2020.1726128. (IF₂₀₂₀=5.35)

[3] Wei Wang, Xinran Wang, Xuemei Li, Qian Pu, Chengyi Luo, Lili Xu, Xinyue Peng and Shiping Liu*. Genetic Manipulation of MicroRNAs in the Silk Gland of Silkworm, Bombyx Mori. Biol Proced Online, 2019, 21, 16. https://doi.org/10.1186/s12575-019-0102-4. (IF2019=4.1)

[4] Xuemei Li, Jinyu Yang, Qian Pu, Xinyue Peng, Lili Xu & Shiping Liu*. Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes, Parasites Vectors, 2019, 12, 460. https://doi.org/10.1186/s13071-019-3714-2. (IF2019=3.0)

[5] Shiping Liu, Keira J. Lucas, Sourav Roy, Jisu Ha, and Alexander S. Raikhel*; Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(40) : 14460-14465. http://www.ncbi.nlm.nih.gov/pubmed/25246546. (IF₂₀₁₄=9.809)

[6] Shiping Liu, Dong Li, Qibin Li, Ping Zhao, Zhonghuai Xiang, Qingyou Xia*; MicroRNAs of Bombyx mori identified by Solexa sequencing, BMC Genomics, 2010, 11(148). https://doi.org/10.1186/1471-2164-11-148. (IF2010=4.21)

[7] Shiping Liu, Song Gao, Danyu Zhang, Jiyun Yin, Zhonghuai Xiang & Qingyou Xia*. MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori. BMC Genomics, 2010, 11, 85. https://doi.org/10.1186/1471-2164-11-85. (IF₂₀₁₀=4.21)

[8] Shiping Liu, Qingyou Xia*, Ping Zhao, Tingcai Cheng, Kaili Hong and Zhonghuai Xiang. Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori). BMC Dev Biol. 2007, 7, 88. https://doi.org/10.1186/1471-213X-7-88. (IF₂₀₀₇=3.51)

[9] Chen E, Chen Z, Li S, Xing D, Guo H, Liu J, Ji X, Lin Y, Liu S, Xia Q*. bmo-miR-2739 and the novel microRNA miR-167 coordinately regulate the expression of the vitellogenin receptor in Bombyx mori oogenesis. Development 2020, 147(8).

[10] Lucas K. J，Zhao B，Liu S，and Raikhel A. S.* Regulation of physiological processes by microRNAs in insects，Curr Opin Insect Sci，2015，11: 1-7.

[11] Chen Z，Nohata J，Guo H，Li S，Liu J，Guo Y，Yamamoto K，Kadono-Okuda K，Liu C，Arunkumar K P，Nagaraju J，Zhang Y，Liu S，Labropoulou V，Swevers L，Tsitoura P，Iatrou K，Gopinathan K P，Goldsmith M. R，Xia Q，and Mita K*. A comprehensive analysis of the chorion locus in silkmoth，Scientific reports 5，2015，16424. （IF=5.578）

[12] Chen Z，Nohata J，Guo H.，Li S，Liu J，Guo Y，Yamamoto K，Kadono-Okuda K，Liu C，Arunkumar K P，Nagaraju J，Zhang Y，Liu S，Labropoulou V，Swevers L，Tsitoura P，Iatrou K，Gopinathan K P，Goldsmith M R，Xia Q，and Mita K. Construction，complete sequence，and annotation of a BAC contig covering the silkworm chorion locus，Scientific data 2，2015，150062.

[13] Chen Q，Cheng D，Liu S，Ma Z，Tan X，and Zhao P.* Genome-wide identification and expression profiling of the fatty acid desaturase gene family in the silkworm，Bombyx mori. Genet Mol Res 13，2014，3747-3760.

[14] Zhong X，Zou Y，Liu S，Yi Q.，Hu C，Wang C，Xia Q.*， and Zhao P. Proteomic-based insight into Malpighian tubules of silkworm Bombyx mori. PLoS ONE，2013，8，e75731.

[15] Jiang L，Cheng T，Dang Y，Peng Z，Zhao P，Liu S，Jin S，Lin P，Sun Q， Xia Q*. Identification of a midgut-specific promoter in the silkworm Bombyx mori. Biochem Biophys Res Commun. 2013，433(4):542-6.

[16] Li Y，Zhao P，Liu S，Dong Z，Chen J，Xiang Z， Xia Q*. A novel protease inhibitor in Bombyx mori is involved in defense against Beauveria bassiana. Insect Biochem Mol Biol. 2012，42 (10): 766-75.

[17] Zhang Y，Dong Z，Liu S，Yang Q，Zhao P，Xia Q*. Identification of novel members reveals the structural and functional divergence of lepidopteran-specific Lipoprotein_11 family. Funct Integr Genomics. 2012，12(4):705-15.

[18] Liu C，Yamamoto K.，Cheng T.，C.Kadono-Okuda K.，Narukawa J.，Liu S，Han Y.，Futahashi R.，Kidokoro K.，Noda H.，Kobayashi I.，Tamura T.，Ohnuma A，Banno Y，Dai F.，Xiang Z，Goldsmith M. R.，Mita K.，Xia Q.* Repression of tyrosine hydroxylase is responsible for the sex-linked chocolate mutation of the silkworm，Bombyx mori. Proc Natl Acad Sci USA，2010，107(29): 12980-5.

[19]  Xu H，Xia Q，Liu C，Cheng T，Zhao P，Duan J，Zha X，and Liu S. Identification and characterization of piggyBac-like elements in the genome of domesticated silkworm，Bombyx mori. Mol Genet Genomics, 2006,276（1）：31-40.

[20] Xia Q. ，Guo Y.，Zhang Z.，Li D.，Xuan Z.，Li Z.，Dai F.，Li Y.，Cheng D.，Li R.，Cheng T.，Jiang T.，Becquet C.，Xu X.，Liu C.，Zha X.，Fan W.，Lin Y.，Shen Y.，Jiang L.，Jensen J.，Hellmann I.，Tang S.，Zhao P.，Xu H.，Yu C.，Zhang G.，Li J.，Cao J.，Liu S，He N.，Zhou Y.，Liu H.，Zhao J.，Ye C.，Du Z.，Pan G.，Zhao A.，Shao H.，Zeng W.，Wu P.，Li C.，Pan M.，Li J.，Yin X.，Li D.，Wang J.，Zheng H.，Wang W.，Zhang X.，Li S.，Yang H.，Lu C.，Nielsen R.，Zhou Z. Wang J.，Xiang Z.，Wang，J. Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science 2009，326(5951): 433-436.

[21] International Silkworm Genome Consortium. The genome of a lepidopteran model insect，the silkworm Bombyx mori. Insect Biochem Mol Biol. 2008, 38(12): 1036-45. IF=2.626

[22] 周兰庭，周挺，高君凌，王伟，吴小燕，黄亚玺，夏庆友，刘仕平*. 家蚕let-7 microRNA 靶基因Bmlin-41 的克隆表达与调控，生物工程学报，2016， 32(5): :635−647.

[23] 何婷，尹权，王伟，黄亚玺，吴小燕，夏庆友，刘仕平*. 利用Bac-to-Bac 杆状病毒系统超量表达家蚕let-7 簇microRNAs.中国农业科学，2016，49(3): 581-592.

[24] 刘仕平，吴小燕，张丹宇，黄亚玺，王伟，赵萍*，夏庆友. 家蚕microRNA 7 靶基因Bmhairy 的鉴定和转录表达模式.中国农业科学，2016，49(1):195-204.

[25] 刘仕平，黄亚玺，尹纪云，吴小燕，周兰庭，王伟，夏庆友*. 家蚕Bmyan基因的克隆表达和作为microRNA 7 靶基因的验证. 生物工程学报， 2015，31(11): 1612–1622.

[26] 刘仕平，夏庆友*. Northern杂交检测家蚕microRNA的技术流程. 蚕业科学.2014，4: 724-729.

联系地址：重庆市北碚区西南大学（南区）家蚕基因组生物学国家重点实验室，400716

电    话： 023-68251938

邮    箱： lsp98668@163.com；lspsm@swu.edu.cn