何华伟
发布时间:2016-11-25 查看 0次   字体:[] [] []

 


教授、博士生导师

重庆市百名海外高层次人才集聚计划

 

简历:

1998-2002

北京林业大学

本科

2002-2007

清华大学

博士

2008-2012

美国西南医学中心

博士后

2012-

西南大学

教授

 

主要科研领域与方向:

1. 蚕丝基因的转录调控

2. 蚕丝蛋白的结构与性能

3. 蚕丝纤维功能化开发与利用

 

科学成就:

主要从事蚕丝基因的转录调控与蚕丝蛋白的结构与性能研究,现任重庆市蚕丝纤维新材料工程技术研究中心副主任,国家自然科学基金委、国家留学基金委、教育部青年长江学者、教育部博士学位论文、国家博士后基金项目评审专家,重庆市高校创新团队研究骨干。

近年来,主持国家自然科学基金面上项目1项、重庆市自然科学基金重点项目1项、中央高校基本科研业务费创新团队项目1项、西南大学博士基金1项、生物大分子国家重点实验室开放基金1项,指导学生主持重庆市研究生科研创新项目1项,中央高校基本业务费“学生双创项目”1项。主研美国自然科学基金(NIH R01)1项、美国心脏病协会基金1项、美国Welch基金1项、国家重点基础研究发展计划(973计划)1项、国家自然科学基金重点项目1项、国家自然科学基金青年项目1项、重庆市自然科学基金1项、中央高校基本科研业务费1项、西南大学博士基金1项。在PNAS、elife、Science signaling、Scienfic reports、Molecular and Cellular Biology、Biophysical Journal、Insect Biochemistry and Molecular Biology等国际知名学术刊物上发表学术论文20余篇。申请国家发明专利2项。

 

代表性论文/论著:

[1]. Huawei He, Taehong Yang, Jonathan R. Terman & Xuewu Zhang. Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration. Proc. Natl. Acad. Sci. U.S.A. 2009 106(37):15610-5.

[2]. Yuxiao Wang*, Huawei He*, Nishi Srivastava, Sheikh Vikarunnessa, Yong-bin Chen, Jing Jiang, Christopher W. Cowan & Xuewu Zhang. Plexins are GTPase Activating Proteins for Rap and are Activated by Induced Dimerization. Science signaling. 2012 5(207): ra6 (*, co-first author).

[3]. Yuxiao Wang*, Heath G. Pascoe*, Chad A. Brautigam, Huawei He, and Xuewu Zhang. Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin. eLife 2013 2:e01279 (*, co-first author).

[4]. Liu, Lina, Yu Li, Yejing Wang, Peng Zhao, Shuguang Wei, Zhenzhen Li, Huaipu Chang, and Huawei He. "Biochemical characterization and functional analysis of the POU transcription factor POU-M2 of Bombyx mori." International Journal of Biological Macromolecules (2016): 701-708.

[5]. Tao, Gang, Lina Liu, Yejing Wang, Huaipu Chang, Ping Zhao, Hua Zuo, and Huawei He. "Characterization of Silver Nanoparticle In Situ Synthesis on Porous Sericin Gel for Antibacterial Application." Journal of Nanomaterials (2016).

[6]. Tao, Gang, Yejing Wang, Lina Liu, Huaipu Chang, Ping Zhao and Huawei He. " Preparation and characterization of silver nanoparticles composited on polyelectrolyte film coated sericin gel for enhanced antibacterial application." Science of advanced materials (2016).

[7]. Meng, Mei, Huawei He, Jing Xiao, Ping Zhao, Jiale Xie and Zhisong Lu. "Controllable in situ synthesis of silver nanoparticles on multilayered film-coated silk fibers for antibacterial application." Journal of colloid and interface science 461 (2016): 369-375.

[8]. Tan, Jia‐Lian, Ting‐Ting Yang, Yu Liu, Xue Zhang, Shu‐Jin Cheng, Hua Zuo and Huawei He. "Sensitive detection of strong acidic condition by a novel rhodamine‐based fluorescent pH chemosensor." Luminescence (2015).

[9]. Kulak, Ozlem, Hua Chen, Brody Holohan, Xiaofeng Wu, Huawei He, Dominika Borek, Zbyszek Otwinowski et al. "Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells." Molecular and cellular biology 35, no. 14 (2015): 2425-2435.

[10]. Guo, Peng-Chao, Zhaoming Dong, Ping Zhao, Yan Zhang, Huawei He, Xiang Tan, Weiwei Zhang, and Qingyou Xia. "Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18." Scientific reports 5 (2015).

[11]. Li, Youshan, Ping Zhao, Huawei Liu, Xiaomeng Guo, Huawei He, Rui Zhu, Zhonghuai Xiang, and Qingyou Xia. "TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi." Insect biochemistry and molecular biology 2015 57:11-19.

[12]. Wang, Yejing, Huawei He*, Lina Liu, Chunyan Gao, Shui Xu, Ping Zhao, and Qingyou Xia. "Inactivation and Unfolding of Protein Tyrosine Phosphatase from Thermus thermophilus HB27 during Urea and Guanidine Hydrochloride Denaturation." PLoS One 2014 9(9): e107932 (*, co-first & corresponding author).

[13]. Guo, Peng-Chao, Zhaoming Dong, Li Xiao, Tao Li, Yan Zhang, Huawei He, Qingyou Xia, and Ping Zhao. "Silk gland-specific proteinase inhibitor serpin16 from the Bombyx mori shows cysteine proteinase inhibitory activity." Biochemical and Biophysical Research Communications (2014).

[14]. Chen, Zhe*, Xiang-Jun Chen*, Mengdie Xia*, Hua-Wei He*, Sha Wang, Huihui Liu, Haipeng Gong, and Yong-Bin Yan. "Chaperone-Like Effect of the Linker on the Isolated C-Terminal Domain of Rabbit Muscle Creatine Kinase." Biophysical Journal. 2012 103(3): 558-66 (*, co-first author).

[15]. Yejing Wang, Huawei He, Sen Li. Effect of Ficoll 70 on Thermal Stability and Structure of Creatine Kinase. Biochemistry (Moscow). 2010 75(5):648-54.

[16]. Zhu Jiang, He Hua-Wei, Li Sen. Macromolecular crowding enhances thermal stability of rabbit muscle creatine kinase. Tsinghua Science and Technology. 2008 13(4):454-9.

[17]. He Hua-Wei*, Feng Shan*, Pang Min, Zhou Hai-Meng, Yan Yong-Bin. Role of the linker between the N- and C-terminal domains in the stability and folding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 2007 39(10):1816-27 (*, co-first author).

[18]. He Hua-Wei*, Li Jie*, Zhao Tong-Jin, Ma Yong, Shi Feng, Zhou Hai-Meng. Exploration of the polar microenvironment around the reactive cysteine in rabbit muscle creatine kinase. Int. J. Biol. Macromol. 2007 41(4):361-8 (*, co-first author).

[19]. Shi Feng*, Zhao Tong-Jin*, He Hua-Wei, Li Jie, Zeng Xian-Gang, Zhou Hai-Meng, Wu Ping. Sodium barbital is a slow reversible inactivator of rabbit-muscle creatine kinase. Biochem. Cell Biol. 2006 84(2):142-7 (*, co-first author).

[20]. Zhang Jun, He Hua-Wei, Wang Qi, Yan Yong-Bin. Sequential events in ribonuclease A thermal unfolding characterized by two-dimensional infrared correlation spectroscopy. Protein Pept. Lett. 2006 13(1):33-40.

[21]. Yan Yong-Bin, Zhang Jun, He Hua-Wei, Zhou Hai-Meng. Oligomerization and aggregation of bovine pancreatic ribonuclease A: characteristic events observed by FTIR spectroscopy. Biophys. J. 2006 90(7):2525-33.

[22]. He Hua-Wei, Zhang Jun, Zhou Hai-Meng, Yan Yong-Bin. Conformational change in the C-terminal domain is responsible for the initiation of creatine kinase thermal aggregation. Biophys. J. 2005 89(4):2650-8.

[23]. Meng Fan-Guo*, Hong Yuan-Kai*, He Hua-Wei, Lyubarev A. E., Kurganov B. I., Yan Yong-Bin, Zhou Hai-Meng. Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys. J. 2004 87(4):2247-54 (*, co-first author).

[24]. Yan Yong-Bin, Wang Qi, He Hua-Wei, Zhou Hai-Meng. Protein thermal aggregation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin. Biophys. J. 2004 86(3):1682-90.

[25]. Yan Yong-Bin*, Wang Qi*, He Hua-Wei, Hu Xin-Yao, Zhang Ri-Qing, Zhou Hai-Meng. Two-dimensional infrared correlation spectroscopy study of sequential events in the heat-induced unfolding and aggregation process of myoglobin. Biophys. J. 2003 85(3):1959-67 (*, co-first author).

 

联系地址:重庆市北碚区西南大学(南区)家蚕基因组生物学国家重点实验室,400716

电    话: 023-68251575

E-mail:hehuawei@swu.edu.cn


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