教授、博士生导师。

简历：

主要科研领域与方向:

分子生物学与功能基因组

蛋白质组与代谢组

蚕丝蛋白功能与性能改造

科学成就：

主要从事功能基因组与蛋白质组学研究，参加完成了家蚕全基因组框架图谱和精细图的绘制工作，特别是在家蚕蛋白质组学研究方面进行了系统和探索性研究，为实验室家蚕蛋白质组学研究的学术带头人，培养了一批从事蛋白质组学研究的科研和技术人材。首次报道了家蚕蚕丝蛋白全组分鉴定的最新研究成果，发现丝蚕白拥有众多具有防御性功能的生物学活性蛋白，其具有在生物医学、材料和保健等领域重要的开发价值。率先取得了蚕丝纤维力学性能改良方面的最新研究成果，通过对蚕丝蛋白成丝环境的遗传操作，获得了高强度、多用途的新型蚕丝，拓展了蚕丝新的应用领域。主持完成了863项目子课题、国家自然科学基金、省部级课题10余项。获四川省科技进步三等奖一项，获国家发明专利10余项。近年来在SCIENCE，Biomacromolecules，Insect Biochem Mol Biol，J. Proteome Res，Proteomics，BMC Genomics，PLoSONE等重要学术刊物上发表研究论文80余篇，其中SCI收录50余篇。

代表性论文：（** co-first author; * corresponding author）

1.    Wang D, Zhang Y, Dong Z, Guo P, Ma S, Guo K, Xia Q, Zhao P*. Serine protease P-IIc is responsible for the digestion of yolk proteins at the late stage of silkworm embryogenesis. Insect Biochem. Mol. Biol. 2016, 74: 42-49.

2.    Zhaoming Dong#, Qianru Song#, Yan Zhang, Shiyi Chen, Xiaolu Zhang, Ping Zhao*, Qingyou Xia. Structure, evolution, and expression of antimicrobial silk proteins, seroins in Lepidoptera, Insect Biochem. Mol. Biol. 2016, 75: 24-31.

3.    Zhaoming Dong, Weiwei Zhang, Yan Zhang, Xiaolu Zhang, Ping Zhao*, Qingyou Xia. Identification and Characterization of Novel Chitin-Binding Proteins from the Larval Cuticle of Silkworm, Bombyx mori. J Proteome Res. 2016, 15(5):1435-1445.

4.    Xin Wang, Yi Li, Kang Xie, Qiying Yi, Quanmei Chen, Xiaohuan Wang, Hong Shen, Qingyou Xia, Ping Zhao*. Ca2+ and endoplasmic reticulum Ca2+-ATPase regulate the formation of silk fibers with favorable mechanical properties. J. Insect Physiol. 2015, 73: 53-59

5.    Zhaoming Dong, Ping Zhao, Yan Zhang, Qianru Song, Xiaolu Zhang, Pengchao Guo, Dandan Wang, Qingyou Xia*. Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori. Sci Rep.2016, 6: 21158.

6.    Xiaomeng Guo#, Zhaoming Dong#, Yan Zhang, Youshan Li, Huawei Liu, Qingyou Xia, Ping Zhao*. Proteins in the Cocoon of Silkworm Inhibit the Growth of Beauveria bassiana. PLoS One, 2016, 11(3):e0151764

7.    Yong Hou, Yan Zhang, Jing Gong, Sha Tian, Jianwei Li, Zhaoming Dong, Chao Guo, Li Peng, Ping Zhao*, Qingyou Xia, Comparative proteomics analysis of silkworm hemolymph during the stages of metamorphosis via liquid chromatography and mass spectrometry. Proteomics. 2016 16(9): 1421-1431.

8.    Zhaoming Dong, Xiaohuan Wang, Yan Zhang, Liping Zhang, Quanmei Chen, Xiaolu Zhang, Ping Zhao*, Qingyou Xia. Proteome profiling reveals tissue-specific protein expression in male and female accessory glands of the silkworm, Bombyx mori. Amino Acids. 2016 48(5):1173-83.

9.    Xin Wang#, Ping Zhao#, Yi Li, Qiying Yi, Sanyuan Ma, Kang Xie, Huifang Chen, Qingyou Xia*. Modifying the mechanical properties of silk fiber by genetically disrupting the ionic environment for silk formation. Biomacromolecules. 2015, 16(10): 3119-3125.

10.  Pengchao Guo, Zhaoming Dong, Ping Zhao, Yan Zhang, Huawei He, Xiang Tan, Weiwei Zhang, Qingyou Xia. Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18. Sci. Rep. 2015, 5:11863.

11.  Yan Zhang#, Ping Zhao#, Zhaoming Dong, Dandan Wang, Xiaomeng Guo, Pengchao Guo, Qianru Song, Weiwei Zhang, Qingyou Xia*, Comparative proteome analysis of multi-layer cocoon of the silkworm, Bombyx mori, PLoS One, 2015, 10(4): e0123403

12.  Quanmei Chen, Zhengang Ma, Xin Wang, Zhiqing Li, Yan Zhang, Sanyuan Ma, Ping Zhao*, Qingyou Xia, Comparative proteomic analysis of silkworm fat body after knocking out fibroin heavy chain gene: a novel insight into cross-talk between tissues, Funct Integr Genomics, 2015, 15(5): 611-37

13.  Quanmei Chen, Xinyu Liu, Ping Zhao, Yanhui Sun, Xinjie Zhao, Ying Xiong, Guowang Xu, Qingyou Xia. GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 2015, 57:41-50.

14.  Youshan Li , Ping Zhao, Huawei Liu, Xiaomeng Guo, Huawei He, Rui Zhu, Zhonghuai Xiang, Qingyou Xia, TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi. Insect Biochem. Mol. Biol. 2015, 57:11-19.

15.  Pengchao Guo#, Zhaoming Dong, Li Xiao, Tao Li, Yan Zhang, Huawei He, Qingyou Xia, Ping Zhao*, Silk gland-specific proteinase inhibitor serpin16 from the Bombyx mori shows cysteine proteinase inhibitory activity, Biochem. Biophys. Res. Comm. 2015, 457(1): 31–36

16.  YouShan Li, Huawei Liu, Rui Zhu, QingYou Xia, Ping Zhao*,. Protease inhibitors in Bombyx mori silk might participate in protecting the pupating larva from microbial infection. Insect Sci. 2015. Epub ahead of print.

17.  Xiang Tan, Xiaoming Hu, Xiaowu Zhong, Quanmei Chen, Qingyou Xia, Ping Zhao*,. Antenna-specific Glutathione S-transferase in male silkmoth Bombyx mori. Int. J. Mol. Sci. 2014, 15(5):7429-7443.

18.  Yan Zhang, Zhaoming Dong, Peiming Gu, Weiwei Zhang, Dandan Wang, Xiaomeng Guo, Ping Zhao*, Qingyou Xia, Proteomics analysis of adult testis from Bombyx mori, Proteomics, 2014,14: 2345–2349

19.  Yan Zhang, Zhaoming Dong, Dandan Wang, Yong Wu, Qianru Song, Peiming Gu, Ping Zhao*, Qingyou Xia, Proteomics of larval hemolymph in Bombyx mori reveals various nutrient-storage and immunity-related proteins, Amino Acids, 2014, 46:1021-1031

20.  Xiao-wu Zhong, Xiao-huan Wang, Xiang Tan, Qing-you Xia,Zhong-huai Xiang, Ping Zhao.       Identification and Molecular Characterization of a Chitin Deacetylase from Bombyx mori Peritrophic Membrane. Int. J. Mol. Sci. 2014, 15, 1946-1961.

21.  Quanmei Chen, Daojun Cheng, Shiping Liu, Zhengang Ma, Xiang Tan, Ping Zhao*,. Genome-wide identification and expression profi ling of the fatty acid desaturase gene family in the silkworm, Bombyx mori. Genet. Mol. Res. 2014, 13(2):3747-3760.

22.  Yi,Qiying#, Zhao,Ping#, Wang Xin, Zou,Yong; Zhong, Xiaowu; Wang, Chen; Xiang,    Zhonghuai; Xia, Qingyou. Shotgun proteomic analysis on the anterior silk gland of the   silkworm: an insight into the biosynthetic fiber spinning process. Proteomics 2013, 13,   2657–2663.

23.  Zhaoming Dong#, Ping Zhao#, Chen Wang, Yan Zhang, Jianping Chen, Xin Wang, Ying Lin, and Qingyou Xia. Comparative Proteomics Reveal Diverse Functions and Dynamic Changes of Bombyx mori Silk Proteins Spun from Different Development Stages. J. Proteome Res. 2013, 12(11):5213-5222.

24.  Liang Jiang#,, Ping Zhao#,, Tingcai Cheng, Qiang Sun, Zhengwen Peng, Yinghui Dang, Xiangwei WU, Genhong Wang, Shengkai Jin, Ping Lin a, Qingyou Xia a,b*. A transgenic animal with antiviral properties that might inhibit multiple stages of infection. Antiviral Research, 98 (2013) 171–173

25.  Liang Jiang#,, Ping Zhao#,, Genhong Wang, Tingcai Cheng, Qiong Yang, Shengkai Jin, Ping Lin, Yang Xiao, Qiang Sun, Qingyou Xia *.Comparison of factors that may affect the inhibitory efficacy of transgenic RNAi targeting of baculoviral genes in silkworm, Bombyx mori. Antiviral Research,97 (2013) 255–263

26.  Xiao-wu Zhong#,Yong Zou#, Shi-ping Liu,Qi-ying Yi, Cui-mei Hu, Chen Wang, Qing-you        Xia, Ping Zhao*. Proteomic-Based Insight into Malpighian Tubules of silkworm Bombyx         mori. PloS ONE, 2013, 8(9):e75731.

27.  Yan Zhang#, Ping Zhao#, Hongli Liu, Zhaoming Dong, Qiang Yang, Dandan Wang, Qingyou Xia*. The synthesis, transportation and degradation of BmLP3 and BmLP7, two highly homologous Bombyx mori 30K proteins, Insect Biochem. Mol. Biol., 2012, 42: 827-834.

28.  Yan Zhang#, Ping Zhao#, Hongli Liu, Zhaoming Dong, Qiang Yang, Dandan Wang, Qingyou Xia*. The synthesis, transportation and degradation of BmLP3 and BmLP7, two highly homologous Bombyx mori 30K proteins, Insect Biochem. Mol. Biol., 2012, 42: 827-834.

29.  Yan Zhang, Zhaoming Dong, Shiping Liu, Qiang Yang, Ping Zhao*, Qingyou Xia. Identification of novel members reveals the structural and functional divergence of     lepidopteran-specific Lipoprotein_11 family. Funct Integr Genomics, 2012, 12(4):705-715.

30.  Zhong X W, Zhang L P, Zou Y, Yi Q Y, Zhao P*, Xia Q Y, Xiang Z H. Shotgun analysis on the peritrophic membrane of the silkworm Bombyx mori. BMB Reports, 2012, 45(11): 665-670.

31.  Zhong X W, Zhao P*, Zou Y, Nie H Y, Yi Q Y, Xia Q Y, Xiang Z H. Proteomic analysis of the immune response of the silkworm infected by Escherichia coli and Bacillus bombyseptieus. Insect Science, 2012, 19(5): 559-569

32.  Li Y, Zhao P, Liu S, Dong Z, Chen J, Xiang Z, Xia Q. A novel protease inhibitor in Bombyx mori is involved in defense against Beauveria bassiana. Insect Biochem Mol Biol, 2012, 42(10): 766-775

33.  Ping Zhao, Zhaoming Dong, Jun Duan, Genhong Wang, Lingyan Wang, Youshan Li, Zhonghuai Xiang, Qingyou Xia*.Genome-Wide Identification and Immune Response Analysis of Serine Protease Inhibitor Genes in the Silkworm, Bombyx mori. PLoS ONE 2012, 7(2): e31168.

34.  Ping Zhao, Gen-Hong Wang, Zhao-Ming Dong, Jun Duan, Ping-Zhen Xu,Ting-Cai Cheng, Zhong-Huai Xiang, Qing-You Xia*.Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori. BMC Genomics, 2010, 11:405.

35.  Yong Hou, Yong Zou, Fei Wang, Jing Gong, Xiaowu Zhong, Qingyou Xia, Ping Zhao*.      Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages. Proteome Science, 2010,8:45.

36.  Ping Zhao, Qing-You Xia, Juan Li, Hiroshi Fujii, Yutaka Banno , Zhong-Huai Xiang. Purification, characterization and cloning of a chymotrypsin inhibitor （CI-9） from the hemolymph of the silkworm, Bombyx mori. The Protein journal, 2007, 26（5）：349-357.

37.  Quan Sun, Ping Zhao*, Ying Lin, Qingyou Xia, honghuai Xiang. Analysis of the Structure and Expression of the 30K protein Genes in Silkworm, Bombyx mori. Insect Science, 2007,14, 5-13.

38.  Qingyou Xia, Zeyang Zhou, Cheng Lu, Daojun Cheng, Fangyin Dai, Bin Li, Ping Zhao, Xingfu Zha, Tingcai Cheng, Chunli Chai，et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori)．Science，2004，306：1937-1940.

39.  谢康, 王鑫, 陈慧芳, 李懿, 宋倩茹, 赵萍*. 家蚕前部丝腺特异表皮蛋白Bm11721的鉴定及表达特征分析. 生物工程学报. 2016, 32(1): 64-73.

40.  陈慧芳，王鑫，谢康，李懿，赵萍*. 家蚕V型ATP酶B亚基的克隆及表达特征. 生物工程学报. 2016, 32(4): 487-496.

41.  李懿，周小英，黎治浪，李建伟，陈世达，郭超，侯勇，赵萍*.家蚕组织蛋白酶基因家族的鉴定及表达特征分析. 生物工程学报. 2016, 32(1):1−13.

42.  王鑫, 李懿, 陈慧芳, 周小英, 谢康, 赵萍*. 利用家蚕杆状病毒表达系统表达家蚕肌质网型钙离子ATP酶蛋白. 生物工程学报. 2015, 31(3): 311-327.

43.  董照明、张艳、杨佩、赵萍、席星航、夏庆友. 蚕丝的基础研究与应用: 从纤维到蛋白质的转型. 蚕业科学. 2015, 41(3): 395-404.

44.  王鑫, 李懿, 陈全梅, 衣启营, 谢康, 吴用, 赵萍*. 家蚕空泡型ATP酶（V-ATPase）基因的基本信息、表达特征分析. 中国农业科学. 2014, 47(8): 1611-1621.

45.  李游山、赵萍*、董照明、邹勇、夏庆友、向仲怀.家蚕丝氨酸蛋白酶抑制剂BmSPI37的克隆、表达及微生物诱导分析. 中国农业科学, 2012, 45(23): 4898-4908,

46.  邹勇、钟晓武、张利平、赵萍*、夏庆友. 家蚕幼虫期和蛹期马氏管差异蛋白质组学分析. 中国农业科学, 2012, 45(9): 1833-1839.

47.  陈全梅、程道军、马振刚、胡晓明、查幸福、赵萍*. 家蚕和野桑蚕脂肪酸脱氢酶desat4全长cDNA和启动子的克隆及其原核表达. 昆虫学报, 2012, 55(8): 885-894.

48.  陈建平、赵萍*、董照明、张艳、石虎、夏庆友. 参与家蚕免疫反应的clip丝氨酸蛋白酶家族基因分析.蚕业科学, 2012, 38(2): 0241-0248.

49.  张利平、钟晓武、聂红毅、王晨、荀利杰、赵萍*、夏庆友. 不同产丝量家蚕品系后部丝腺的蛋白质组学分析. 蚕业科学, 2012, 38(3): 0468-0474.

50.  聂红毅、钟晓武、衣启营、张利平、邹勇、赵萍*. 家蚕精巢中小热激蛋白在不同发育时期的蛋白质组学分析. 中国农业科学, 2011, 44(9): 1923-1930

51.  邹勇、罗冰、段军、钟晓武、赵萍*、夏庆友. 家蚕蛋白质数据检索系统. 蚕业科学, 2011, 37(6):0 993-0999.

52.  陈全梅、谭祥、杨强、胡晓明、马振刚、赵萍*. 家蚕Atlastin基因(BmATL)的鉴定及表达模式. 蚕业科学, 2011,37(2): 0206-0214.

53.  聂红毅、钟晓武、邹勇、衣启营、赵萍*、夏庆友. 家蚕精巢蛋白质的双向电泳及质谱分析. 昆虫学报, 2010, 53(4): 369-378.

54.  董照明、赵萍*、王凌燕、李游山、张艳、夏庆友. 家蚕丝氨酸蛋白酶抑制剂基因serpin16的表达规律及体外重组表达. 蚕业科学, 2010, 36(2): 0236-0242.

专利：

1.    赵萍，王鑫，谢康，衣启营，马三垣，夏庆友，家蚕钙离子-ATP酶基因重组表达载体及其应用，ZL2013 1 0516484.0

2.    赵萍，李游山，夏庆友，向仲怀，家蚕蛋白酶抑制剂BmSPI38及其制备方法和应用，ZL2012 1 0063274.6

3.    赵萍，谭祥，夏庆友，胡晓明，陈全梅，家蚕谷胱甘肽-S-转移酶BmGSTD4及其基因，ZL2011 1 0423280.3

4.    夏庆友，衣启营，赵萍，王鑫，马三垣，王峰，家蚕表皮蛋白BmCP231启动子及其重组表达载体和应用，ZL2012 1 0085897.3

5.    夏庆友，衣启营，赵萍，王鑫，马三垣，徐汉福，家蚕表皮蛋白BmCP274启动子及其重组表达载体和应用，ZL2012 1 0085855.X

专著：

1.    赵萍，蚕的基因组（第四章：蚕的基因家族；第五章：家蚕丝氨酸蛋白酶及其抑制剂；第十二章：蚕的蛋白质组）, 科技出版社. 72.3万字，2013

2.    赵萍，蚕体解剖生理学（第十章：丝腺），高等教育出版社，44万字，2015

联系地址：　400716，西南大学家蚕基因组生物学国家重点实验室

电　　话：　023-68250885

传　　真：　023-68251128

E-mail：　zhaop@swu.edu.cn