夏庆友
发布时间:2016-11-25 查看 0次   字体:[] [] []

西南大学教授、博士生导师

家蚕基因组生物学国家重点实验室主任

国家重点基础研究发展计划(973计划)首席科学家

“长江学者”奖励计划特聘教授

国家自然科学二等奖获得者

“万人计划”百千万工程领军人才

 

简历:

1981-1985

西南农业大学

本科生

1985-1996

四川省农科院蚕研所

工作

1991-1996

西南农业大学

博士生

1997-2001

日本九州大学

博士后、特别研究员

2000-

西南大学

教授、博导

2002-

农业部蚕桑功能基因组与生物技术重点开放实验室

副主任

2005–2007

西南大学蚕学与生物技术学院

院长

2005-2012

教育部家蚕基因组学重点实验室

副主任

2006-

西南大学蚕学与系统生物学研究所

副所长

2007-2016

西南大学生物技术学院

院长

2011-

家蚕基因组生物学国家重点实验室

主任

 

主要科研领域与方向:

家蚕分子生物学

基因组与功能基因组

利用转基因等技术进行家蚕品种改良和素材创新等


科学成就:

一、完成中国家蚕基因组计划

2004年绘制了6X家蚕全基因组框架图,负责项目策划、测序指挥到论文撰写,以第一作者在Science上发表成果。2008年与日本合作,绘制了家蚕基因组9X精细图谱,并作为客座编辑组织了Insect Biochem Mol Biol《家蚕基因组特别刊》,以第一作者发表了主题论文。2009年完成了40个蚕品系的基因组重测序和高精度遗传变异图谱绘制。发现1600万个SNP位点、31万个插入缺失突变和3.5万个基因组结构变异,发现家蚕由中国野桑蚕而来的驯化为单一事件,并以第一作者在Science上发表成果。

二、建立家蚕功能基因组研究平台技术

主持构建了家蚕遗传数据库SilkDB,成为国际蚕学和昆虫学领域基因组权威数据平台;主持研制了世界首张家蚕全基因组Oligo芯片,完成了家蚕10万条EST测序和32个重要组织、器官的基因表达分析。主持建立了国际一流的基因定位克隆、RNAi、转基因和基因定向敲除等平台。整体水平居国际领先,部分成果已发表于Annu Rev Entomol、Genome Bio、Nucleic Acids Res和JBC等。

三、在重要基因鉴定和功能解析方面有众多发现

提出了蚕丝蛋白合成、性别决定、免疫调控和发育与变态等为家蚕功能基因组研究中的首要目标并得到国内外同行认可。围绕该四大性状,系统鉴定分析Fib-H、Fib-L、Bmsage等主要性状相关调控基因,重点克隆研究了30余个关键基因的功能,获授权专利50余项,在Nat Biotechnol、PNAS、PLoS pathogens、 J Proteome Res 、Genomics、BMC Dev Biol、和Insect Biochem Mol Biol等杂志发表家蚕研究论文超过300篇,影响因子合计超过400分。

四、国际交流与人才培养

多次被相关国际学术会议选为执行主席和特邀报告人,并在澳大利亚国立大学、墨尔本大学等四所知名大学讲学。先后主持8个重要国际合作项目。被聘为教育部“长江学者”和“长江学者与创新团队发展计划”创新团队带头人,973首席科学家(2次),“万人计划”百千万工程领军人才,省部学科及学术技术带头人,主持973、863、基金委重点项目等项目30余个,获“十一五”国家科技计划执行突出贡献奖。先后获国家自然科学二等奖、重庆市自然科学一等奖、光华工程科技奖青年奖、全国优秀科技工作者、中国青年科技奖、全国五一劳动奖章、全国师德先进个人、全国纺织行业年度创新人物、桑麻纺织科技大奖、重庆杰出贡献英模和重庆市优秀共产党员等荣誉和称号。已培养毕业博士研究生31人、硕士研究生96人,指导留学生2人,他们中先后获中国青少年科技创新奖、全国“挑战杯”一等奖、澳大利亚化学感受科学大会“最佳学生奖”等多项奖励。

 

代表性论文/论著:

  1. [1]. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J, Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, Wan Y, Zhu Y, Yu M, Shen W, Wu D, Xiang Z, Yu J, Wang J, Li R, Shi J, Li H, Li G, Su J, Wang X, Li G, Zhang Z, Wu Q, Li J, Zhang Q, Wei N, Xu J, Sun H, Dong L, Liu D, Zhao S, Zhao X, Meng Q, Lan F, Huang X, Li Y, Fang L, Li C, Li D, Sun Y, Zhang Z, Yang Z, Huang Y, Xi Y, Qi Q, He D, Huang H, Zhang X, Wang Z, Li W, Cao Y, Yu Y, Yu H, Li J, Ye J, Chen H, Zhou Y, Liu B, Wang J, Ye J, Ji H, Li S, Ni P, Zhang J, Zhang Y, Zheng H, Mao B, Wang W, Ye C, Li S, Wang J, Wong GK, Yang H; Biology Analysis Group. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 2004, 306(5703):1937-40.

  2. [2]. Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, Cheng T, Jiang T, Becquet C, Xu X, Liu C, Zha X, Fan W, Lin Y, Shen Y, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu H, Yu C, Zhang G, Li J, Cao J, Liu S, He N, Zhou Y, Liu H, Zhao J, Ye C, Du Z, Pan G, Zhao A, Shao H, Zeng W, Wu P, Li C, Pan M, Li J, Yin X, Li D, Wang J, Zheng H, Wang W, Zhang X, Li S, Yang H, Lu C, Nielsen R, Zhou Z, Wang J, Xiang Z*, Wang J*. Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science. 2009, 326(5951):433-6.

  3. [3]. Xia Q, Cheng D, Duan J, Wang G, Cheng T, Zha X, Liu C, Zhao P, Dai F, Zhang Z, He N, Zhang L, Xiang Z. Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol. 2007,8(8):R162.

  4. [4]. Xia QY, Fujii H, Kusakabe T, Banno Y. Identification of three annexin IX isoforms generated by alternative splicing of the carboxyl-terminal exon in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2001,32(1):9-14.

  5. [5]. Liu C, Yamamoto K, Cheng TC, Kadono-Okuda K, Narukawa J, Liu SP, Han Y, Futahashi R, Kidokoro K, Noda H, Kobayashi I, Tamura T, Ohnuma A, Banno Y, Dai FY, Xiang ZH, Goldsmith MR, Mita K, Xia QY*. Repression of tyrosine hydroxylase is responsible for the sex-linked chocolate mutation of the silkworm, Bombyx mori. Proc Natl Acad Sci U S A. 2010, 107(29):12980-5.

  6. [6]. Duan J, Li R, Cheng D, Fan W, Zha X, Cheng T, Wu Y, Wang J, Mita K, Xiang Z, Xia Q*. SilkDB v2.0: a platform for silkworm (Bombyx mori ) genome biology. Nucleic Acids Res. 2010,38(Database issue):D453-6.

  7. [7]. Zhao P, Dong Z, Duan J, Wang G, Wang L, Li Y, Xiang Z, Xia Q*. Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm, Bombyx mori. PLoS One. 2012;7(2):e31168.

  8. [8]. Xia QY, Li S, Feng QL. Advances in silkworm studies accelerated by the genome sequencing of Bombyx mori. Annu Rev Entomol. 2014; 59:513-536.

  9. [9]. Lin P, Cheng T, Ma S, Gao J, Jin S, Jiang L, Xia Q. Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death. PLoS Pathog. 2016, 29;12(3):e1005527.

  10. [10]. Wang X, Zhao P, Li Y, Yi Q, Ma S, Xie K, Chen H, Xia Q.*. Modifying the Mechanical Properties of Silk Fiber by Genetically Disrupting the Ionic Environment for Silk Formation. Biomacromolecules. 2015;16(10):3119-3125.

  11. [11]. Ma L, Xu H, Zhu J, Ma S, Liu Y, Jiang RJ, Xia Q*, Li S*. Ras1(CA) overexpression in the posterior silk gland improves silk yield. Cell Res. 2011, 21(6):934-43.

  12. [12]. Wang F, Xu H, Wang Y, Wang R, Yuan L, Ding H, Song C, Ma S, Peng Z, Peng Z, Zhao P, Xia Q.*. Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application. Acta Biomaterialia. 2014; 10(12):4947-55.

  13. [13]. Zhao XM, Liu C, Jiang LJ, Li QY, Zhou MT, Cheng TC, Mita K, Xia QY.*. A juvenile hormone transcription factor Bmdimm-fibroin H chain pathway is involved in the synthesis of silk protein in silkworm, Bombyx mori. J Biol Chem. 2015, 290(2):972-986.

  14. [14]. Lin Y, Meng Y, Wang YX, Luo J, Katsuma S, Yang CW, Banno Y, Kusakabe T, Shimada T*, Xia QY.*.Vitellogenin receptor mutation leads to the oogenesis mutant phenotype “scanty vitellin” of the silkworm,Bombyx mori. J Biol Chem. 2013, 288(19):13345-13355.

  15. [15]. Zhao P, Wang GH, Dong ZM, Duan J, Xu PZ, Cheng TC, Xiang ZH, Xia QY*. Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori. BMC Genomics. 2010,11:405.

  16. [16]. Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M, Zhang H, Zhang G, Li D, Dong Y, Zhao L, Lin Y, Cheng D, Yu J, Sun J, Zhou X, Ma K, He Y, Zhao Y, Guo S, Ye M, Guo G, Li Y, Li R, Zhang X, Ma L, Kristiansen K, Guo Q, Jiang J, Beck S, Xia Q*, Wang W*, Wang J*. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol. 2010, 28(5):516-20.

  17. [17]. Li D, Guo Y, Shao H, Tellier LC, Wang J, Xiang Z, Xia Q*. Genetic diversity, molecular phylogeny and selection evidence of the silkworm mitochondria implicated by complete resequencing of 41 genomes. BMC Evol Biol. 2010, 10:81.

  18. [18]. Liu S, Li D, Li Q, Zhao P, Xiang Z, Xia Q*. MicroRNAs of Bombyx mori identified by Solexa sequencing. BMC Genomics. 2010,11:148.

  19. [19]. Liu S, Gao S, Zhang D, Yin J, Xiang Z, Xia Q*. MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori. BMC Genomics. 2010,11:85.

  20. [20]. Huang L, Cheng T, Xu P, Cheng D, Fang T, Xia Q*. A genome-wide survey for host response of silkworm, Bombyx mori during pathogen Bacillus bombyseptieus infection. PLoS One. 2009,4(12):e8098.

  21. [21]. Gong DP, Zhang HJ, Zhao P, Xia QY*, Xiang ZH. The odorant binding protein gene family from the genome of silkworm, Bombyx mori. BMC Genomics. 2009,10:332.

  22. [22]. Huang L, Cheng T, Xu P, Duan J, Fang T, Xia Q*. Immunoglobulin superfamily is conserved but evolved rapidly and is active in the silkworm, Bombyx mori. Insect Mol Biol. 2009,18(4):517-30.

  23. [23]. Jiang L, Zhao P, Wang G, Cheng T, Yang Q, Jin S, Lin P, Xiao Y, Sun Q, Xia Q*. Comparison of factors that may affect the inhibitory efficacy of transgenic RNAi targeting of baculoviral genes in silkworm, Bombyx mori. Antiviral Res. 2013, 97(3):255-263.

  24. [24]. Lin P, Cheng T, Jin S, Wu Y, Fu B, Long R, Zhao P, Xia Q.*. PC, a Novel Oral Insecticidal Toxin from Bacillus bombysepticus Involved in Host Lethality via APN and BtR-175.Sci Rep.2015; 5:11101.

  25. [25]. Couble P, Mita K, Xia Q. Editorial: Silkworm genome. Insect Biochem Mol Biol. 2008, 38(12):1035.

  26. [26]. Zha X, Xia Q*, Duan J, Wang C, He N, Xiang Z. Dosage analysis of Z chromosome genes using microarray in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2009, 39(5-6):315-21.

  27. [27]. Cheng D, Xia Q*, Duan J, Wei L, Huang C, Li Z, Wang G, Xiang Z. Nuclear receptors in Bombyx mori: insights into genomic structure and developmental expression. Insect Biochem Mol Biol. 2008, 38(12):1130-7.

  28. [28]. Duan J, Xia Q*, Cheng D, Zha X, Zhao P, Xiang Z. Species-specific expansion of C2H2 zinc-finger genes and their expression profiles in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2008 ,38(12):1121-9.

  29. [29]. Liu S, Xia Q*, Zhao P, Cheng T, Hong K, Xiang Z. Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori). BMC Dev Biol. 2007,7:88.

  30. [30]. Guo PC, Dong Z, Zhao P, Zhang Y, He H, Tan X, Zhang W, Xia Q. *. Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18. Sci Rep.2015, 5:11863.

  31. [31]. Dong Z, Zhao P, Wang C, Zhang Y, Chen J, Wang X, Lin Y, Xia Q. *.Comparative proteomics reveal diverse functions and dynamic changes of Bombyx mori silk proteins spun from different development stages. J Proteome Res. 2013, 12(11):5213-5222.

  32. [32]. Hou Y, Xia Q*, Zhao P, Zou Y, Liu H, Guan J, Gong J, Xiang Z. Studies on middle and posterior silk glands of silkworm (Bombyx mori) using two-dimensional electrophoresis and mass spectrometry. Insect Biochem Mol Biol. 2007, 37(5):486-96.

  33. [33]. Gong DP, Zhang HJ, Zhao P, Lin Y, Xia QY*, Xiang ZH. Identification and expression pattern of the chemosensory protein gene family in the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2007, 37(3):266-77.

  34. [34]. Xu HF, Xia QY*, Liu C, Cheng TC, Zhao P, Duan J, Zha XF, Liu SP. Identification and characterization of piggyBac-like elements in the genome of domesticated silkworm, Bombyx mori. Mol Genet Genomics. 2006, 276(1):31-40.

  35. [35]. Cheng T, Zhao P, Liu C, Xu P, Gao Z, Xia Q*, Xiang Z. Structures, regulatory regions, and inductive expression patterns of antimicrobial peptide genes in the silkworm Bombyx mori. Genomics. 2006, 87(3):356-65.

  36. [36]. Cheng DJ, Xia QY*, Zhao P, Wang ZL, Xu HF, Li GR, Lu C, Xiang ZH. EST-based profiling and comparison of gene expression in the silkworm fat body during metamorphosis. Arch Insect Biochem Physiol. 2006, 61(1):10-23.

  37. [37]. Yang C, Lin Y, Liu H, Shen G, Luo J, Zhang H, Peng Z, Chen E, Xing R, Han C, Xia Q*. The Broad-Complex (Br-C) transcriptional factor plays a critical role in vitellogenin transcription in the silkworm Bombyx mori. BBA-Gen Subjects. 2014, 1840(9):2674-2684.

  38. [38]. Zha XF, Xia QY*, Zhao P, Li J, Duan J, Wang ZL, Qian JF, Xiang ZH. Detection and analysis of alternative splicing in the silkworm by aligning expressed sequence tags with the genomic sequence. Insect Mol Biol. 2005, 14(2):113-9.

  39. [39]. Wang J, Xia Q, He X, Dai M, Ruan J, Chen J, Yu G, Yuan H, Hu Y, Li R, Feng T, Ye C, Lu C, Wang J, Li S, Wong GK, Yang H, Wang J, Xiang Z, Zhou Z, Yu J. SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res. 2005, 1;33(Database issue):D399-402.

  40. [40]. Cheng TC, Xia QY*, Qian JF, Liu C, Lin Y, Zha XF, Xiang ZH. Mining single nucleotide polymorphisms from EST data of silkworm, Bombyx mori, inbred strain Dazao. Insect Biochem Mol Biol. 2004, 34(6):523-30.


出版专著:

夏庆友,向仲怀 主编. 《蚕的基因组》,科学出版社,2013.5

夏庆友, 向仲怀 主编. 《家蚕基因组计划2000-2007》,西南师范大学出版社, 2008.6

夏庆友,向仲怀 主编. 《家蚕基因组计划2008-2009》(上、下册),西南师范大学出版社,2010.12

 

联系地址:重庆市北碚区西南大学(南区)家蚕基因组生物学国家重点实验室,400716

电    话: 023-68250099

传    真: 023-68251128

E-mail:xiaqy@swu.edu.cn


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