博士，研究员，博士生导师

简历 

主要科研领域与方向

研究领域：昆虫激素信号转导与生长发育调控

研究方向：1. 家蚕内分泌激素的合成调控与信号转导通路

2. 家蚕内分泌激素对幼虫组织生长与凋亡及成虫器官分化与发育的分子调控

3. 果蝇高糖模型建立及糖脂代谢平衡调控

招生专业：遗传学、发育生物学

科学成就

主要从事家蚕生长发育内分泌激素调控的分子机理研究，并利用果蝇模型探究糖脂代谢稳态维持的分子调控机制。主持国家自然科学基金4项、重庆市自然科学基金2项、中央高校科研业务费专项1项、西南大学博士启动基金1项，主研973、863、国家自然科学基金重点项目等课题10余项。先后在Journal of Biological Chemistry、Insect Biochemistry and Molecular Biology、Insect Science、Archives of Insect Biochemistry and Physiology、PLoS One、International Journal of Molecular Sciences等学术期刊发表研究论文40余篇，其中SCI收录25篇。参编《蚕的基因组》等专著3部；获授权发明专利1项。

国家自然科学基金通讯评审专家、教育部学位中心研究生学位论文评审专家；Molecular Genetics and Genomics、Journal of Insect Science、Entomological Research、Gene、《昆虫学报》、《蚕业科学》等学术期刊审稿人；全国专业标准化技术委员会委员、重庆市生物化学与分子生物学学会理事、中国蚕学会会员。

代表性论文（* corresponding author）

[1]. Meng M, Cheng D*, Peng J, Qian W, Li J, Dai D, Zhang T, Xia Q*. The homeodomain transcription factors Antennapedia and POU-M2 regulate the transcription of the steroidogenic enzyme gene Phantom in the silkworm. J Biol Chem, 2015, 290(40):24438-52

[2]. Meng M, Liu C, Peng J, Qian W, Qian H, Tian L, Li J, Dai D, Xu A, Li S, Xia Q*, Cheng D*. Homeodomain protein Scr regulates the transcription of genes involved in juvenile hormone biosynthesis in the silkworm. Int J Mol Sci, 2015, 16(11):26166-85

[3]. Qian W, Kang L, Zhang T, Meng M, Wang Y, Li Z, Xia Q, Cheng D*. Ecdysone receptor (EcR) is involved in the transcription of cell cycle genes in the silkworm. Int J Mol Sci, 2015,16(2):3335-49

[4]. Cheng D, Qian W, Wang Y, Meng M, Wei L, Li Z, Kang L, Peng J, Xia Q*. Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1. PLoS One, 2014, 9(10): e109111

[5]. Cheng D, Meng M, Peng J, Qian W, Kang L, Xia Q*. Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects. Genet Mol Biol, 2014, 37(2):444-59

[6]. Cheng D, Qian W, Meng M, Wang Y, Peng J, Xia Q*. Identification and expression profiling of the BTB domain-containing protein gene family in the silkworm, Bombyx mori. Int J Genomics, 2014, 2014:86506

[7]. Cheng D, Peng J, Meng M, Wei L, Kang L, Qian W, Xia Q*. Microarray analysis of the juvenile hormone response in larval integument of the silkworm, Bombyx mori. Int J Genomics, 2014, 2014:426025

[8]. Cheng D, Xia Q*, Duan J, Wei L, Huang C, Li Z, Wang G, Xiang Z. Nuclear receptors in Bombyx mori: insights into genomic structure and developmental expression. Insect Biochem Mol Biol, 2008,38(12):1130-1137

[9]. Cheng D, Xia Q*, Zhao P, Wang Z, Xu H, Li G, Lu C, Xiang Z. EST-based profiling and comparison of gene expression in the silkworm fat body during metamorphosis. Arch Insect Biochem Physiol, 2006, 61(1):10-23

[10]. Li Z, Cheng D, Wei L, Zhao P, Shu X, Tang L, Xiang Z, Xia Q*. The silkworm homolog of Methoprene-tolerant (Met) gene reveals sequence conservation but function divergence. Insect Science, 2010, 17(4):313-324

[11]. Li Z, Cheng D, Mon H, Tatsuke T, Zhu L, Xu J, Lee J, Xia Q, Kusakabe T*. Genome-wide identification of Polycomb target genes reveals a functional association of Pho with Scm in Bombyx mori. PLoS One, 2012, 7(4):e34330

[12]. Xia Q, Cheng D, Duan J, Wang G, Cheng T, Zha X, Liu C, Zhao P, Dai F, Zhang Z, et al. Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol, 2007, 8(8): R162

[13]. Wei L, Li Z, Cheng D, Kusakabe T, Pan M, Duan J, Wang Y, Lu C. RNAi silencing of the SoxE gene suppresses cell proliferation in silkworm BmN4 cells. Mol Biol Rep, 2014,41(7): 4769-81

[14]. Duan J, Li R, Cheng D, Fan W, Zha X, Cheng T, Wu Y, Wang J, Mita K, Xiang Z, Xia Q*. SilkDB v2.0: a platform for silkworm (Bombyx mori) genome biology. Nucleic Acids Res, 2010, 38 (Database issue):D453-456

[15]. Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M, Zhang H, Zhang G, Li D, Dong Y, Zhao L, Lin Y, Cheng D, Yu J, et al. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol, 2010, 28(5):516-520

[16]. Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, et al. (2009) Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).Science, 2009, 326(5951): 433-436

[17]. Xia Q, Wang J, Zhou Z, Li R, Fan W, Cheng D, Cheng T, Qin J, Duana J, Xu H, et al. The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochem Mol Biol, 2008, 38(12):1036-1045

[18]. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science, 2004, 306 (5703):1937-1940

联系地址：重庆市北碚区 西南大学 家蚕基因组生物学国家重点实验室

邮    编：400715

电　　话：023-68251987

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E-mail：chengdj@swu.edu.cn；chengdjhv@163.com