三田和英
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三田和英 教授
Prof. MITA KAZUEI

家蚕基因组生物学国家重点实验室教授
国家“外专千人计划”特聘专家


经历:

1. 教育经历:
1970.4-1975.3     日本京都大学    博士     高分子化学,主要从事聚电解质溶液的物理化学研究

1966.4-1970.3     日本京都大学    学士     高分子化学

 

2.工作经历:

1975-1993     日本国立放射科学研究所研究员             从事染色质结构研究

1994-2001.3    日本国立放射科学研究所DNA测序及生物信息学方向负责人,领导分裂酵母的cDNA目录及基因组测序项目。自1997年起,与Maeda博士(加州大学戴维斯分校)及岛田博士(东京大学)启动了家蚕基因项目

2001.4-2006.3   日本国立农业生物科学研究所昆虫基因组实验室主任    主持家蚕基因组项目

2006.4-2008.3   日本国立农业生物科学研究所昆虫基因组单元负责人    主持家蚕基因组项目

2008.4-2013.2   日本国立农业生物科学研究所、特别高级研究员      主持家蚕基因项目及注释项目

2013.3-至今    家蚕基因组生物学国家重点实验室            国家“外专千人计划”特聘专家


研究方向:
   家蚕W染色体分析、性别决定级联研究、家蚕进化研究、斜纹夜蛾基因组测序。


科学成就:

三田和英教授,为国家“外专千人计划”特聘专家。曾任日本国立农业生物科学研究所昆虫基因组单元负责人、特别高级研究员,主持家蚕基因项目及注释项目,作为日本家蚕基因组计划的负责人领导日本家蚕基因研究团队开展家蚕基因组计划,构建了家蚕30万条EST数据库及BAC文库,并利用shotgun技术获得3倍深度的家蚕基因组数据构建家蚕全长cDNA文库构建和大规模测序分析,掌握了迄今为止世界最高质量和数量的全长cDNA数据库。此外,三田和英教授还在家蚕数据库构建、性别决定机制、人工选择进化、转基因、免疫及抗性等多个领域做出了重要贡献,取得了众多的高水平成果。近年在PNAS, Nucleic Acids Research, DNA research, J Biol Chem, Genetics等国际学术刊物上发表高水平论文200余篇;同时,在多个国际学术组织及杂志如美国细胞生物学学会、日本分子生物学学会、日本蚕业科学学会、BMC基因组学、BMC发育生物学、基因、昆虫分子生物学、昆虫生理学等国际知名杂志担任要职。


获得荣誉:
       1. 2005 荣获日本蚕业科学协会“家蚕基因组分析”特别荣誉

2. 2011 荣获国际蚕业委员会路易牧场奖

3. 2012 中国国家“外专千人计划”特聘专家

4. 2015 荣获重庆市外国专家“重庆友谊奖”


代表性论文:
1.  Ravikumar Gopalapillai*, Keiko Kadono-Okuda, Kozo Tsuchida+, Kimiko Yamamoto, Junko Nohata, Masahiro Ajimura and Kazuei Mita (2006) Lipophorin receptor from the silkworm, Bombyx mori: cDNA cloning,genomic structure, alternative splicing and isolation of a new isoform.J. Lipid Res. 47, 1005-1013.

2.  Yamamoto, K., Narukawa, J., Kadono-Okuda, K., Nohata, J., Sasanuma, M., Suetsugu, Y., Banno, Y., Fujii, H., Goldsmith, M.R. and Mita, K.(2006) Construction of a Single Nucleotide Polymorphism Linkage Map for the Silkworm, Bombyx mori, Based on BAC End-sequences.Genetics 173,  151-161.

3.  Katsuma, S., Daimon, T., Mita, K. and Shimada, T.(2006) Lepidopteran ortholog of Drosophila Breathless is a receptor for the baculoviral fibroblast growth factor.J. Virol. 80, 5474-5481.

4.  Negre V, Hotelier T, Volkoff AN, Gimenez S, Cousserans F, Mita K, Sabau X, Rocher J, Lopez-Ferber M, d'Alencon E, Audant P, Sabourault C, Bidegainberry V, Hilliou F, Fournier P (2006)SPODOBASE : an EST database for the lepidopteran crop pest Spodoptera. BMC Bioinformatics 7, 322-331.

5.  Yonemura N, Sehnal F, Mita K, Tamura T. (2006) Protein composition of silk filaments spun under water by caddisfly larvae. Biomacromolecules 7, 3370-3378.

6.  Abe H, Fujii T, Tanaka N, Yokoyama T, Kakehashi H, Ajimura M, Mita K, Banno Y, Yasukochi Y, Oshiki T, Nenoi M, Ishikawa T, Shimada T (2008) Identification of the female-determining region of the W chromosome in Bombyx mori. Genetica 133, 269-282..

7.  Takasu Y, Yamada H, Tamura T, Sezutsu H, Mita K, Tsubouchi K. (2007) Identification and characterization of a novel sericin gene expressed in the anterior middle silk gland of the silkworm Bombyx mori. Insect Biochem Mol Biol. 37,1234-40.

8.  Shinpei Kawaoka, Kosuke Minami, Susumu Katsuma, Kazuei Mita, and Toru Shimada (2008) Developmentally synchronized expression of two Bombyx mori Piwi subfamily genes, SIWI and BmAGO3 in germ-line cells. Biochem.Biophys. Res. Commun.367(4): 755-760.

9.  Yamamoto K, Nohata J, Kadono-Okuda K, Narukawa J, Sasanuma M, Sasanuma S, Minami H, Shimomura M, Suetsugu Y, Banno Y, Osoegawa K, de Jong P,Goldsmith MR, Mita K. (2008) A BAC-based integrated linkage map of the silkworm, Bombyx mori. Genome Biology 9: R21.

10.  Noda H, Kawai S, Koizumi Y, Matsui K, Zhang Q, Furukawa S, Shimomura M, Mita K. (2008) Annotated ESTs from various tissues of the brown planthopper Nilaparvata lugens: a genomic resource for studying agricultural pests. BMC Genomics 9:117.

11.  Ito K, Kidokoro K, Sezutsu H, Nohata J, Yamamoto K, Kobayashi I, Uchino K, Kalyebi A, Eguchi R, Hara W, Tamura T, Katsuma S, Shimada T, Mita K, Kadono-Okuda K. (2008) Deletion of a gene encoding an amino acid transporter in the midgut membrane causes resistance to a Bombyx parvo-like virus. Proc. Natl. Acad. Sci. USA  105: 7523-7527.

12.  Daimon T, Taguchi T, Meng Y, Katsuma S, Mita K, Shimada T. (2008) beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. J. Biol. Chem. 283: 15271-15279.

13.  Okamoto S, Futahashi R, Kojima T, Mita K, Fujiwara H. (2008) A catalogue of epidermal genes: genes expressed in the epidermis during larval molt of the silkworm Bombyx mori. BMC Genomics 9: 396.

14.  Kawaoka S, Hayashi N, Katsuma S, Kishino H, Kohara Y., Mita K, Shimada T. (2008) Bombyx small RNAs: Genomic defense system against transposons in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1058-1065.

15.  Tanaka H, Ishibashi J, Fujita K, Nakajima Y, Sagisaka A, Tomimoto K, Suzuki N, Yoshiyama M, Kaneko Y, Iwasaki T, Sunagawa T, Yamaji K, Asaoka A, Mita K, Yamakawa M. (2008) A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori. Insect Biochem Mol Biol. 38: 1087-1110.

16.  Futahashi R, Sato J, Meng Y, Okamoto S, Daimon T, Yamamoto K, Suetsugu  Y, Narukawa J, Takahashi H, Banno Y, Katsuma S, Shimada T, Mita K, Fujiwara H. (2008) yellow and ebony are the Responsible Genes for the Larval Color Mutants of the Silkworm Bombyx mori. Genetics 180: 1995-2005,

17.  The International Silkworm Genome Consortium. (2008) The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochem. Mol. Biol. 38: 1036-1045.

18.  Osanai-Futahashi M, Suetsugu Y, Mita K, Fujiwara H. (2008) Genome-wide screening and characterization of transposable elements and their distribution analysis in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1046-1057.

19.  Futahashi R, Okamoto S, Kawasaki H, Zhong Y, Iwanaga M, Mita K, Fujiwara H. (2008) Genome-wide identification of cuticular protein genes in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1138-1146.

20.  Zou Z, Picheng Z, Weng H, Mita K, Jiang H.(2009) A comparative analysis of serpin genes in the silkworm genome.Genomics 93: 367-375.

21.  Meng Y, Katsuma S, Daimon T, Banno Y, Uchino K, Sezutsu H, Tamura T, Mita K, Shimada T. (2009) The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. J.Biol. Chem. 284: 11698-11705.

22.  Arunkumar, K.P., Mita, K., Nagaraju, J. (2009) Silkworm Z chromosome is enriched in testis-specific genes. Genetics 182: 493-501.

23.  Yonemura N, Mita K, Tamura T, Sehnal F. (2009) Conservation of Silk Genes in Trichoptera and Lepidoptera. J. Mol. Evol. 68: 641-653.

24.  Shimomura M, Minami H, Suetsugu Y, Ohyanagi H, Satoh C, Antonio B, Nagamura Y, Kadono-Okuda K, Kajiwara H, Sezutsu H, Nagaraju J, Goldsmith  MR, Xia Q, Yamamoto K, Mita K. (2009) KAIKObase: An integrated silkworm genome database and data mining tools. BMC Genomics 10: 486.

25.  Ito K, Katsuma S, Yamamoto K, Kadono-Okuda K, Mita K, Shimada T. (2010) Yellow-E determines the color pattern of larval head and tail spots of the silkworm, Bombyx mori. J. Biol. Chem. 285: 5624-5629.

26.  d’Alençon E, Sezutsu H, Legeai F, Permal E, Bernard-Samain S, Gimenez S, Gagneur C, Cousserans F, Shimomura S, Brun-Barale A, Flutie T, Couloux A, East P, Gordon K, Mita K, Quesneville H, Fournier P, Feyereisen R. (2010) Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome  rearrangements. Proc. Natl. Acad. Sci. USA 107: 7680-7685.

27.  Liu C, Yamamoto K, Cheng T, Okuda-Kadono K, Narukawa J, Liu S, Han Y, Noda H, Kobayashi I, Futahashi R, Tamura T, Ohnuma A, Banno Y, Dai F, Xiang Z, Goldsmith MR, Mita K, Xia Q. (2010) Repression of tyrosine hydroxylase caused the sex-linked chocolate mutation of the silkworm, Bombyx mori. Proc. Natl. Acad. Sci. USA 107: 12980-12985.

28.  Suetsugu Y, Futahashi R, Kanamori H, Kadono-Okuda K, Sasanuma S, Narukawa J, Ajimura M, Jouraku A, Namiki N, Shimomura M, Sezutsu H, Osanai-Futahashi M, Suzuki M, Daimon T, Shinoda T, Taniai K, Asaoka K,  Niwa R, Kawaoka S, Katsuma S, Tamura T, Noda H, Kasahara M, Sugano S, Suzuki Y, Fujiwara H, Kataoka H, Arunkumar K, Tomar A, Nagaraju J, Goldsmith M R, Feng Q, Xia Q, Yamamoto K, Shimada T, and Mita K (2013) Large Scale Full-Length cDNA Sequencing Reveals a Unique Genomic Landscape in a Lepidopteran Model Insect, Bombyx mori. G3 3: 1481-1492.


联系方式:400716,西南大学 家蚕基因组生物学国家重点实验室
电   话:+86-23-6825 1683
传   真:+86-23-68251128
E-mail : mitakazuei@gmail.com



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